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Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
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Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

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Francesco Busardò

International Advisory Board Khosrow Adeli Canada
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Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

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Chiara Riva
Biomedia srl
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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

Articoli con TAG: intervalli di riferimento.

Risultati preliminari per la definizione dell’intervallo di riferimento per l’indoxyl solfato (indicano) nelle urine
Preliminary results for the definition of a reference interval for urine indoxyl sulfate (indican).
<p>Introduction: the term &ldquo;gut dysbiosis&rdquo; refers to an alteration in the composition and functions of the microbiota that causes the loss of beneficial microorganisms and species diversity with the potential growth of harmful bacteria. This condition has been related to many pathologies, both intestinals and extraintestinals. One method for evaluating the dysbiosis is the determination of urinary metabolites related to intestinal fermentative processes. Among these different molecules, indoxyl-sulfate (IS) is well studied. In this paper, the IS measurement was performed in a group of subjects in order to establish a reference interval.<br />Methods: the measurement was carried out by HPLC method using a&nbsp; fluorescence detector on early morning urine void. The results were expressed for urine creatinine concentration.<br />Results: in a group of 68 subjects (35 males, 33 females), the mean IS concentration was 22.3 &micro;mol/mmol creatinine with a standard deviation of 6.8 and a range of 8.2-36.6. The reference interval at 95%, calculated with the &ldquo;robust method&rdquo;, was 9.0-36.3 &micro;mol/mmol creatinine. The 90% confidence intervals, calculated with the &ldquo;boostrap method&rdquo;, for the lower and upper limit of the reference interval were 6.8-11.5 and 34.0-38.6 respectively.<br />Conclusion: this study is&nbsp; one of the first contributions to the definition of a reference interval for this metabolite in the first morning urine void.</p>
Biochimica Clinica ; 46(3) 225-230
Contributi Scientifici - Scientific Papers