Member area login
You don't have or don't remember the password!
Click Here
Editor-in-chief
Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

EIC Assistant
Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada


Publisher
Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

Editorial Secretary
Chiara Riva
Biomedia srl
Via L. Temolo 4, 20126 Milano
Tel. 0245498282
email: biochimica.clinica@sibioc.it

--------------------

ISSN print: 0393 – 0564
ISSN digital: 0392- 7091



Articoli con TAG: HIV

Indicazioni per l’armonizzazione dell’intervallo terapeutico nel monitoraggio plasmatico dei farmaci antiretrovirali
Indications for the harmonization of the plasma therapeutic ranges in the antiretroviral drugs monitoring
Biochimica Clinica ; 46(3) 247-254
Documenti - Documents
 
Pharmacogenetic markers able to predict lipid-related parameters in a cohort of ritonavir treated patients
<p>Introduction: Ritonavir (RTV) could cause lipodistrofy and body fat redistribution. Pharmacogenetics could explain part of variability in RTV treatment outcome, but few data are present in literature concerning its influence on lipid-associated parameters. For these reasons, aim of this study is to describe the role of single nucleotide polymorphisms (SNPs) in genes involved in lipids and RTV transport and metabolism in affecting lipid-related biomarkers in a cohort of HIV-infected patients.<br />Methods: adult HIV-affected patients, being on RTV-containing antiretroviral treatment for at least 6 months, were enrolled at the &ldquo;Amedeo di Savoia&rdquo; hospital in Turin (Italy). Genotypes were assessed through real-time PCR.<br />Results: 99 patients were recruited for the study. The following associations were suggested: ABCB13435 TT on total cholesterol and triglycerydes, ABCB12677 on viral load, ABCC2-1249 AA on glucose,ABCC2 -24 GA/AA on total cholesterol, low density lipoproteins cholesterol and triglycerides, ABCG21194+928 CC on pancreatic amylase, HNF4 975 CG/GG on total cholesterol, low density lipoproteins cholesterol, VEGF-1154 AA on lactate dehydrogenase.<br />Discussion: This work was the first analyzing genetic polymorphisms affecting lipid-related markers in a cohort of RTV-treated patients. Further analyses are warranted to confirm these data and evaluate their influence on cardiovascular risk.</p>
Biochimica Clinica ; 44(3) 249-254
Contributi Scientifici - Scientific Papers