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Maria Stella Graziani

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Martina Zaninotto

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Giuseppe Agosta

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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da G.C. Zucchelli

Stato dell’arte dell’immunodosaggio dei peptidi natriuretici di tipo B
State of the art of B-type natriuretic peptide (BNP) immunoassays
<p>Recent studies have demonstrated that the&nbsp;precursor of BNP (proBNP) constitutes the major part of BNP-related peptides detectable in plasma of patients with&nbsp;heart failure by the commercially available immunoassays considered specific for the BNP hormone. Since proBNP&nbsp;significantly cross-reacts with commercial immunoassays for BNP, manufacturers should test and clearly declare the&nbsp;cross-reaction with proBNP in their BNP methods. Owing to the differences in cross-reaction with proBNP as well as&nbsp;in specificity, respectively, for the NH2- or COOH-terminal part of the peptide hormone chain, BNP immunoassays show&nbsp;significant between-method differences. Immunoassays for NT-proBNP, which all use standard materials and&nbsp;antibodies provided by the same company, show lower differences (generally minore del 20%). Clinicians should take into&nbsp;account these differences among methods when they compare results obtained from different laboratories, which use&nbsp;different BNP immunoassays. Accordingly, the use of a common decisional limit for all BNP immunoassay methods,&nbsp;as suggested by the most recent international guidelines, may be unreliable.</p>
Biochimica Clinica ; 39(5) 312-325
Rassegne - Reviews