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Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

EIC Assistant
Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada

Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

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Chiara Riva
Biomedia srl
Via L. Temolo 4, 20126 Milano
Tel. 0245498282


ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da S. Zago

Una anemia in gravidanza da indagare attentamente
A pregnant woman with anemia to be carefully investigated
<p>A 29-year-old woman, of Italian origin (Treviso, Italy), during her second pregnancy, was examined at the out-patients section of the laboratory a few years ago, to investigate the anemic status. Among the clinical information available on that occasion, there was a diagnosis of hemolytic anemia due to a possible haemoglobinopathy, that had led to a splenectomy at the age of 24 years. The hemoglobin pattern performed using a HPLC instrument (Variant II, Bio-Rad, USA) did not show the presence of any hemoglobin variant, but a reduced value of HbA2 was observed. At that time, the anemia was not particularly marked considering the pregnancy (92 g/L (r.i. 120-160). Further investigations to check the presence of unstable variants and the characterization of the variants by mass spectrometry, together with the clinical history of the family, allowed to characterize an unstable variant of the alpha globin chains (Hb Torino) and to identify a condition of alpha thalassemia in trans. During her third pregnancy, the monitoring of the glycemic status showed particularly low values of glycated hemoglobin (HbA1c) due to the instability of the Hb variant present.</p>
Biochimica Clinica ; 46(2) e4-e7
Casi Clinici - Case Report