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Maria Stella Graziani

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Martina Zaninotto

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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da MR. Varì

Cannabis e cannabinoidi naturali: focus su aspetti legislativi, clinici e di medicina di laboratorio
Cannabis and natural cannabinoids: focus on legislative, clinical and laboratory medicine aspects
S. Marinelli  |  MR. Varì  |  G. Basile  | 
<p>&nbsp;</p><p style="text-align:justify"><span style="font-size:9.0pt">The use of Cannabis and its derivatives is increasingly at the center of intense political debates related to regulation or prohibition. Beyond the political or ideological debates, a scientifically based information policy is however necessary to understand the differences between Cannabis used for recreational purposes, light Cannabis that can be legally sold, and Cannabis administered for therapeutic purposes, with a special focus to the analytical methods that can be utilized to differentiate the different types of Cannabis. Regarding the different properties, considered that the differentiation between the various types of Cannabis, (recreational, light or medical) is essential for legal purposes, the role played by the analytical toxicology laboratories is crucial. A number of studies with light and medical Cannabis have illustrated the possible use of Cannabidiol (CBD) as a possible biomarker to identify the type of Cannabis, since CBD is predominant in light Cannabis; the ratio of CBD to &Delta;9-tetrahydrocannabinol (THC), the only cannabinoid with psychotropic effects, has been suggested to be of particular relevance.&nbsp;</span><span style="font-size:9pt">This review aims to analyze the current legislative, medical and laboratory medicine aspects connected to Cannabis in Italy, by focusing on the legislation currently in force and on the role of the toxicology laboratory in differentiating the different types of Cannabis.</span></p>
Biochimica Clinica ; 46(3) 190-200
Rassegne - Reviews
Sistema Nazionale di Allerta Precoce, una piattaforma web per il contrasto alla diffusione delle Nuove Sostanze Psicoattive
The National Early Warning System, a web-based platform to prevent the spread of New Psychoactive Substances
<p>Introduction: the abuse of New Psychoactive Substances (NPS) has been a major issue since the 1990s, due to the significant impact this phenomenon has on the society and public health. The Italian legislation, in line with the European legislation, is aimed to limit the NPS use in the Country through different intervention strategies.<br />Methods: the Department for Anti-Drug Policies (DPA) of the Presidency of the Council of Ministers, has activated in Italy the National Early Warning System (SNAP) on NSP reporting, aimed at the early detection of potentially health-threatening phenomena related to the appearance of NPSs in the market. A second aim of the SNAP is the promotion of the technical-analytical expertise of laboratories for the detection of these substances.<br />Since June 2016, the DPA, where the National Focal Point (NFP) for the verification of the phenomenon of drug dependence is established, has entrusted the coordination of SNAP with the National Centre for Addiction and Doping (NCAD) of the &ldquo;Istituto Superiore di Sanit&agrave;&rdquo;. The Centre works with several partners, including the Pavia Poison Control Centre for clinical toxicology, the Unit of Forensic Toxicology of Sapienza University of Rome for bio-toxicological aspects, and the Central Directorate for Anti-Drug Services for national coordination of seizures operated by law enforcement agencies. To implement this network of collaboration, the NCAD has developed and activated a strategic &#39;web application&#39; that simplifies the collection of information across the Country, optimizing incoming/outgoing reports between all the involved authorities.<br />Results: the analysis of the information collected on NPS during 2020 through the SNAP platform, highlighted the circulation of 47 NSPs in Europe, including two synthetic cannabinoids with potential public health risks and the emergence of NPS belonging to the class of benzodiazepines and the benzimidazole family.<br />Conclusions: The SNAP is an important tool for identifying and notifying the spread of NSPs in our Country very rapidly.</p>
Biochimica Clinica ; 45(3) 267-280
Contributi Scientifici - Scientific Papers