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Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

EIC Assistant
Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
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Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
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Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

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Chiara Riva
Biomedia srl
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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da M. Vannucci

Interferenza da anticorpi eterofili e anti fosfatasi alcalina in un paziente sottoposto ad intervento cardiochirurgico di David
Etherophilic and anti-alkaline phosphatase antibodies interference in a patient undergoing David procedure
F. Balboni  |  M. Biagioli  |  V. Comito  |  S. Rapi  |  M. Vannucci  | 
<p>We describe the case of a 47 years old male patient who underwent cardiac surgery for valve sparing root replacement (known as David procedure), in September 2018. In the post-operative period and during the rehabilitation stage, the patient was constantly monitored with the measurement of cardiac troponin I (cTnI), performed in different hospital facilities using different cTnI analytical methods. In the rehabilitation clinic, cTnI [measured with Access AccuTnI+3 method (Beckman Coulter)] was found steadily raising, so the patient was readmitted to the hospital to undergo a coronary angiography. The coronary arteries were found free from critical lesions and the cTnI [measured with Advia Centaur cTnI Ultra method, (Siemens Healthcare)] was repeatedly negative. This finding rose the suspect of an analytical interference in the Access AccuTnI+3 method. This was actually the case: heterophile and anti-alkaline phosphatase antibodies were demonstrated in the patient sample; they both were responsible for the elevated values of cTnI.</p>
Biochimica Clinica ; 44(2) S097-S100
Casi Clinici - Case Report