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Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

EIC Assistant
Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada

Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

Editorial Secretary
Chiara Riva
Biomedia srl
Via L. Temolo 4, 20126 Milano
Tel. 0245498282


ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da M. Tocchini

L’immunosottrazione può rivelarsi più utile dell’immunofissazione nella tipizzazione di componenti monoclonali IgAl
Immunosubtraction technique is sometimes more useful than immunofixation for typing IgAl monoclonal components
<p>The characterization of a monoclonal component involves a serum protein electrophoresis and the immunotyping. &nbsp;Serum samples from 6 patients showed a slight anomalous peak in the b-region of the serum electrophoresis. &nbsp;Using immunofixation, only a heavy chains were typed, suggesting an a heavy chain disease.&nbsp;In 4 of these cases, the problem was observed when the monoclonal component was detected for the first time, with a potential risk of misdiagnosis.&nbsp;The 4 cases account for 5% of new monoclonal component IgA detected in the considered period.&nbsp;Although there are several reports on the lower sensitivity of immunosubtraction in comparison with immunfixation, we report here some exceptions about the usefulness of immunosubtraction in the identification of small IgAl monoclonal components.</p>
Biochimica Clinica ; 39(5) 326-330
Contributi scientifici - Scientific Papers
Prevalenza di componenti monoclonali in una popolazione di donatori di sangue
Prevalence of monoclonal components in a blood donor population
<p>Occasional detection of monoclonal&nbsp;components (MC) is frequently attributable to the clinically silent presence of monoclonal gammopathy of&nbsp;undetermined significance, which nevertheless carries a small risk of developing into myeloma over the years. Over&nbsp;2007-2012, 9902 blood donors underwent serum protein electrophoresis (SPE) during routine blood tests. Any&nbsp;abnormalities in their SPE pattern were confirmed and characterized by serum protein immunofixation (IFE). A MC&nbsp;was detected in 58 donors (0.59%), the frequency being significantly higher in males (56/6564) than in females&nbsp;(2/3338) (P &lt;0.0001). There was a 2.2% prevalence in individuals &gt;50 years. The monoclonal immunoglobulins were&nbsp;IgG (70.7%), IgM (15.5%), IgA (12.1%) and IgD (1.7%). The involved light chains were <span style="font-family:symbol">k</span> in 67.2% and<span style="font-family:symbol"> l</span> in 32.8% of&nbsp;cases. The Bence-Jones protein test was always negative in 18 examined cases. The prevalence of MC in individuals&nbsp;&gt;50 years was similar to that reported in other studies and higher than that reported in the &rsquo;70-&rsquo;80s. These findings&nbsp;may indicate a potential increase in the number of myeloma cases.</p>
Biochimica Clinica ; 38(4) 292-294
Contributi scientifici - Scientific Papers
Antigene carboidratico 125 (CA-125) vs. proteina 4 dell’epididimo umano (HE4) in una popolazione di donne con massa pelvica
Carbohydrate antigen 125 (CA-125) vs. human epididymis protein 4 (HE4) in a population of women with pelvic mass
<p>Aim of this study was to compare the diagnostic performance of CA-125 and HE4 for epithelial ovarian&nbsp;carcinoma (OC) in 505 consecutive women referred to our hospital for an adnexal mass. The population consisted of&nbsp;18 (3.6%) patients with OC (13 in post-menopausal status, 72.2%) and 487 patients with a benign mass (171 in postmenopausal&nbsp;status, 35.1%). Employed diagnostic thresholds were 35 kU/L for CA-125 and 70 or 140 pmol/L for HE4&nbsp;in pre-menopause and post-menopause, respectively. CA-125 and HE4 concentrations were significantly lower in&nbsp;patients with benign mass in comparison to women with OC. Overall sensitivity and specificity were higher for HE4&nbsp;than for CA-125: 94.4% vs. 61.1% (P=0.04) and 91.0% vs. 82.8% (P=0.0002). False positive results for CA-125 and&nbsp;HE4 were found in 16.8% and 6.6% of women in pre-menopause and in 18.1% and 13.5% of women in postmenopause,&nbsp;respectively. Our results confirmed a higher specificity for HE4 vs. CA-125. Thus, the additional&nbsp;evaluation of HE4 would enable a more accurate referral of patients at risk for OC to the gynecological oncology&nbsp;services.</p>
Biochimica Clinica ; 37(3) 190-194
Contributi Scientifici - Scientific Papers
Un caso di mieloma IgDk
The IgDk myeloma: a case report
Biochimica Clinica ; 36(6) 441-442
Lettere all'Editore - Letters to the Editor