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Editor-in-chief
Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

EIC Assistant
Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada


Publisher
Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

Editorial Secretary
Chiara Riva
Biomedia srl
Via L. Temolo 4, 20126 Milano
Tel. 0245498282
email: biochimica.clinica@sibioc.it

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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091



BC: Articoli scritti da F. Spolaore

Impatto dell’emergenza COVID-19 nei laboratori: esperienze e opinioni dei SIBioC Young Scientists
The impact of COVID-19 emergency in clinical laboratories: experiences and opinions of SIBioC Young Scientists
<p>The recent pandemic status declared worldwide for the spreading of the new coronavirus-SARS-CoV-2 has emphasized the key role of the Laboratory Medicine in the health care process. In this context, the clinical laboratories needed to rapidly reorganize the internal workflow to face the emergency and to continue ensuring rapid and accurate responses. This has been possible only thanks to the contribution of all the personal working in the laboratory, including administrative staff, nurses, technical staff, and clinical chemists. The competence and the commitment of the Young Scientists (YS), can be considered an essential contribution to the efficient and successful management of the pandemic in clinical laboratories.<br />This paper reports the experiences and the opinions of some of the members of the SIBioC YS Study Group, who have been involved in the clinical laboratory management of the COVID-19 pandemic. The paper is focused to present and discuss the use of the molecular and serological tests for the screening and diagnosis of COVID-19, the reorganization of laboratories, the development of panels of biochemical markers for organ damage and cardiovascular involvement diagnosis. Finally, issues are addressed regarding the importance of safety procedures for biohazard containment, and of future research and development perspectives, thanks to the availability of biological specimens from patients affected by COVID-19, safely and correctly stored in biobanks, together with the associated clinical data.</p>
Biochimica Clinica ; 44(4) 021-022
COVID-19 - COVID-19
 
Sindrome simil-Kawasaki in una bambina positiva al SARS-CoV-2: l’approccio di laboratorio
Kawasaki–like disease in a positive SARS-CoV-2 child: a laboratory approach
<p>This case describes the clinical presentation of a Kawasaki-like syndrome, an inflammatory process that can affect all blood vessels of the body and may cause cardiac complications, such as coronary artery aneurysms. Patients are typically children, the majority of them are below 5-year-old, who initially present high fever and non-specific skin rash. The girl who came to our attention showed typical clinical symptoms and the diagnosis of Kawasaki disease was made based on the clinical evaluation, anamnesis and interpretation of laboratory results. This case came to our observation during the recent Coronavirus pandemic infection in Northeast of Italy, and can be classified as a Kawasaki-like syndrome. The laboratory data recorded at the time of diagnosis and during the follow-up are presented and discussed.</p>
Biochimica Clinica ; 44(4) 035-036
COVID-19 - COVID-19
 
La Medicina di Laboratorio: gli specialisti di domani
Laboratory Medicine: specialists of tomorrow
<p>Laboratory Medicine rides the wave of technological progress, the metamorphosis of information systems and data management. The Young Specialist is not a mere observer, but rather takes a leading role in this change, taking advantage of the opportunities offered by &ldquo;omics&rdquo; technologies, capturing new ideas and innovative stimuli that lead to a new concept of work and research oriented to health and prevention. Thanks to the support of international web platforms, training and exchange programs supported by the International Scientific Societies and Federations that favor professional and scientific growth, Young Scientists work in a global context. In this scenario, the SIBioC Young Scientists Study Group, with the auspices of SIBioC, EFLM and IFCC, organized a meeting on &quot;Laboratory Medicine: Specialists of tomorrow&quot; with the aim of discussing and highlighting some of the most important challenges, such as technological progress, training and internationalization of young people. Finally, the future of laboratory medicine looks at a multidisciplinary approach that leads to integrated diagnosis, identification of the frail patient, the use of the Point of Care Testing as an indispensable tool in crisis areas, making the dialogue between physician and laboratory specialist a fundamental step for the diagnosis and treatment with the final aim of a better outcome for the patient.</p>
Biochimica Clinica ; 43(4) 424-434
Documenti - Documents
 
Armonizzazione della diagnostica ematologica: lo stato della valutazione dei reticolociti
Harmonization in hematology: the status of reticulocyte count
E. Piva  |  S. Secchiero  |  F. Spolaore  |  F. Tosato  |  M. Plebani  | 
<p>Harmonization is a crucial step in laboratory&nbsp;medicine to provide reliable information. The reticulocyte count and even more maturity parameters and indices seem&nbsp;to be still highly variable, despite their proven clinical usefulness. Three hematology analyzers (Siemens Advia 2120,&nbsp;Sysmex XN-1000, Mindray BC-6800) were used to assess reticulocyte count (percentage and absolute count),&nbsp;parameters and indices of blood samples from 82 adult patients. Results from 92 participant laboratories to the last&nbsp;3 cycles (2012-2015) of EQA program of the Center of Biomedical Research were also evaluated. Statistical&nbsp;comparisons demonstrated an excellent correlation among the 3 instruments for reticulocyte count, both in&nbsp;percentage and absolute values. A systematic, not proportional difference in immature reticulocyte fraction results&nbsp;was observed between Advia 2120 and the other two analyzers, which conversely showed an excellent correlation&nbsp;between them. For the measurement of reticulocyte hemoglobin content, we found a systematic proportional&nbsp;difference between Advia 2120 and XN-1000, an excellent concordance between Advia 2120 and BC 6800 and a&nbsp;systematic not proportional difference between XN-1000 and BC 6800. Comparison between reticulocyte mean&nbsp;volume results obtained with Advia 2120 and BC 6800 showed a good correlation, even if systematic differences&nbsp;between the two methods were observed. For the reticulocyte counts the interlaboratory variability showed a CV&nbsp;Z10%, except for Advia 2120. EQA demonstrated the need of harmonization of reference intervals, which should go&nbsp;together with the harmonization of analytical methods for a correct clinical interpretation.</p>
Biochimica Clinica ; 40(3) 208-216
Contributi scientifici - Scientific Papers