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Maria Stella Graziani

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Giuseppe Agosta

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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da I. Soriente

Alterazioni morfologiche dei megacariociti nelle sindromi mielodisplastiche associate a delezione del braccio lungo del cromosoma 5 [del(5q)], 7 [del(7q)] e 20 [del(20q)] e monosomia del cromosoma 7
Morphological alterations of megakaryocytes in myelodysplastic syndromes with del(5q), del(20q), -7 and del(7q)
<p>Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic stem cell disorders&nbsp;characterized by ineffective and inefficient hematopoiesis and a high risk of progression to acute myeloid leukemia.&nbsp;The MDS diagnosis is based on morphological evaluation of dysplasia. The choice of therapy depends on the&nbsp;prognostic stratification that is based on peripheral number of cytopenias, on the percentage of blasts and on&nbsp;karyotype according to the criteria IPSS (International Prognostic Scoring System). Some aspects of megakaryocyte&nbsp;dysplasia correlate with specific chromosomal abnormalities. We evaluated morphological characteristics of&nbsp;megakaryocytes in bone marrow of 28 patients with MDS presenting a complex karyotype, in which at least one of&nbsp;the following anomalies was present: -7, del(7q), del(5q) and del(20q). Megakaryocyte dysplasia was confirmed on&nbsp;at least 30 elements for each sample according to 2008 WHO criteria. In MDS with del(5q), megakaryocytes were&nbsp;slightly smaller with an eccentric and not lobed nucleus. Monosomy 7 was associated with evidence of&nbsp;micromegakaryocytes and a negative prognostic significance. Isolated deletion of the 20q was associated with&nbsp;dysmorphic megakaryocytes and has favorable prognosis, especially when at diagnosis this alteration is isolated and&nbsp;it has been recently associated with refractory thrombocytopenia. In summary, we showed that each of the&nbsp;considered genetic alterations was associated with a specific megakaryocytic morphology.</p>
Biochimica Clinica ; 40(3) 229-233
Contributi scientifici - Scientific Papers