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Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

EIC Assistant
Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
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Via L. Temolo 4, 20126 Milano

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Giuseppe Agosta

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Chiara Riva
Biomedia srl
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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da T. Scacchetti

Determinazione delle immunoglobuline E specifiche
SIBioC Position statement about in vitro immunoglobulin E (IgE) testing
<p>The aim of this document is to contribute to increase the knowledge of the diagnostic significance and the clinical value of laboratory tests that are included in the in vitro category of allergy tests. In this context, the clinical benefits of the in vitro determination of specific immunoglobulins E (IgE) for complete extracts or single allergen molecules is to be strongly reaffirmed. This test is to be consider central in the diagnostic algorithm of allergic diseases compared to Skin Prick Test.</p>
Biochimica Clinica ; 42(1) 74-78
Documenti SIBioC - SIBioC Documents
Sensibilità al glutine: il test di attivazione dei basofili (BAT) può aiutare nella diagnosi differenziale?
Gluten hypersensitivity: basophil activation test (BAT) may help in the differential diagnosis
T. Scacchetti  |  D. Debbia  |  E. Boni  |  T. Trenti  | 
<p>Gluten hypersensitivity: basophil activation test (BAT) may help in the differential diagnosis? The main forms&nbsp;of gluten-related disorders are wheat allergy (WA), celiac disease (CD) and possibly immune-mediated disease&nbsp;(gluten sensitivity). S-IgE play an essential role in WA. For CD tests available are anti-tissue transglutaminase (tTG)&nbsp;IgA, anti-endomysium (EMA) and deamidated gliadin peptides (DGP) antibodies IgG particular. For other immunemediated&nbsp;diseases there is currently no test available. The usefulness of basophil activation test (BAT) in anaphylactic&nbsp;adverse reactions, late-onset allergy has been demonstrated. We report the case of a woman of 46 years old with&nbsp;disorders of wheat tied overt clinical signs, intestinal and extra-intestinal symptoms, whose tests above were all&nbsp;negative. Only the BAT showed a stimulation of basophils exposed (52.9%) to extract wheat. We diagnosed gluten&nbsp;sensitivity (GS) on the basis of an algorithm for the differential diagnosis of gluten-related disorders, including CD,&nbsp;GS and WA. We believe that the BAT confirms a hypersensitivity reaction to wheat not-IgE-mediated, not CD.</p>
Biochimica Clinica ; 40(4) e31-e34
Casi clinici - Case report