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Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
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Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
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Matteo Vidali

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Francesco Busardò

International Advisory Board Khosrow Adeli Canada
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Eric Kilpatrick UK
Magdalena Krintus Poland
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Via L. Temolo 4, 20126 Milano

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Giuseppe Agosta

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Chiara Riva
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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da S. Sale

Piastrine grigie sullo striscio di sangue periferico: patologia o artefatto?
Gray platelets on peripheral blood smear: syndrome or artifact?
Y. Pancione  |  M. Fumi  |  S. Sale  |  V. Rocco  | 
<p>This case reports on a 6-year-old child, suffering&nbsp;from phenylketonuria treated with levetiracetam. The complete blood count showed degranulated platelets, confirmed&nbsp;by optical microscopy of the peripheral blood smear. Medical history revealed no bleeding or thrombocytopenia, so a&nbsp;correlation between the phenomenon and the pharmacological treatment was postulated. However, among the&nbsp;adverse effect of this drug, only cases of drug-induced thrombocytopenia are known. From a literature research, we&nbsp;were able to retrieve a description of a &quot;pseudo gray platelet syndrome induced by EDTA&quot;. The blood sampling was&nbsp;thus repeated using sodium-citrate as anticoagulant besides EDTA; smears were performed using these samples and&nbsp;directly from a finger stick. The smear from the EDTA sample confirmed the presence of degranulated platelets; while&nbsp;the one from the sodium-citrate sample showed no platelet abnormalities. Platelet morphology was also normal in the&nbsp;smear from the finger stick. Pseudo Gray Syndrome Platelet (PGSP) by EDTA is an &ldquo;in vitro&rdquo; phenomenon not&nbsp;associated with bleeding disorders. The observation of different peripheral blood smears (EDTA, sodium-citrate and&nbsp;finger stick) allowed us to correctly identified a harmless condition, distinguishing it from the true gray platelet&nbsp;syndrome, a much more severe disorder.</p>
Biochimica Clinica ; 40(3) e15-e17
Casi clinici - Case report