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Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

EIC Assistant
Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada

Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

Editorial Secretary
Chiara Riva
Biomedia srl
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Tel. 0245498282


ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da V. Rocco

Piastrine grigie sullo striscio di sangue periferico: patologia o artefatto?
Gray platelets on peripheral blood smear: syndrome or artifact?
Y. Pancione  |  M. Fumi  |  S. Sale  |  V. Rocco  | 
<p>This case reports on a 6-year-old child, suffering&nbsp;from phenylketonuria treated with levetiracetam. The complete blood count showed degranulated platelets, confirmed&nbsp;by optical microscopy of the peripheral blood smear. Medical history revealed no bleeding or thrombocytopenia, so a&nbsp;correlation between the phenomenon and the pharmacological treatment was postulated. However, among the&nbsp;adverse effect of this drug, only cases of drug-induced thrombocytopenia are known. From a literature research, we&nbsp;were able to retrieve a description of a &quot;pseudo gray platelet syndrome induced by EDTA&quot;. The blood sampling was&nbsp;thus repeated using sodium-citrate as anticoagulant besides EDTA; smears were performed using these samples and&nbsp;directly from a finger stick. The smear from the EDTA sample confirmed the presence of degranulated platelets; while&nbsp;the one from the sodium-citrate sample showed no platelet abnormalities. Platelet morphology was also normal in the&nbsp;smear from the finger stick. Pseudo Gray Syndrome Platelet (PGSP) by EDTA is an &ldquo;in vitro&rdquo; phenomenon not&nbsp;associated with bleeding disorders. The observation of different peripheral blood smears (EDTA, sodium-citrate and&nbsp;finger stick) allowed us to correctly identified a harmless condition, distinguishing it from the true gray platelet&nbsp;syndrome, a much more severe disorder.</p>
Biochimica Clinica ; 40(3) e15-e17
Casi clinici - Case report
Armonizzazione del referto ematologico con l’impego di unità di misura conformi al Sistema Internazionale
Harmonization of the hematology test report by using units according to the International System (SI)
<p>The&nbsp;need for harmonizing hematology reporting units remains an important challenge for the clinical laboratory community.&nbsp;In 2014, the SIBioC Diagnostic Hematology Study Group (GdS-DE) carried out a survey to assess the state-of-the-art&nbsp;of the Italian hematology laboratories. The survey showed that the majority of laboratories report results using units of&nbsp;measurement that do not conform to SI. In some European countries, initiatives to harmonize hematology reporting&nbsp;units were taken some years ago. In particular, in the UK for the reporting of laboratory hematology results the SI units&nbsp;have been used since April 2013 (this includes hemoglobin and mean corpuscular hemoglobin concentrations in g/L).&nbsp;The aim of this GdS-DE proposal is to advocate a national initiative for promoting the adoption of SI units for&nbsp;hematology reporting. This will optimise the comparability of results among different laboratories and prevent the&nbsp;misinterpretation of data, which may worsen the patient&#39;s outcome.</p>
Biochimica Clinica ; 39(6) 627-630
Opinioni - Opinions
Stato dell’arte della diagnostica ematologica nei servizi di Medicina di Laboratorio in Italia
State of the art of diagnostic hematology in clinical laboratories in Italy
<p>One of the challenges for laboratories&nbsp;performing diagnostic hematology is the harmonization of diagnostic process. This is a consequence of the rapid&nbsp;technological advancement that has characterized the recent development of automated blood cell counters, with&nbsp;new automation models and new types of parameters provided. In this context, the SIBioC Study Group of Diagnostic&nbsp;Hematology has conducted a survey among Italian laboratories. The aim was to focus on the different ways of&nbsp;organizing the service. The questionnaire consisted of 36 questions, made available on the SIBioC website for&nbsp;members and non members of the society. Responses were received via e-mail, regular mail or fax from 78&nbsp;laboratories. The survey showed differences among laboratories with regard to the organizational models adopted,&nbsp;degree of automation and completeness of final laboratory reports. However, a relative homogeneity in the validation<br />rules, review rate, turnaround time and amount and type of available resources was observed. An unexpected finding&nbsp;was the low relevance that the majority of laboratories gave to the occurrence of atypical lymphocytes, thus not&nbsp;reporting the presence of these cells in interpretative comments.</p>
Biochimica Clinica ; 39(1) 025-040
Contributi scientifici - Scientific Papers