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Maria Stella Graziani

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Martina Zaninotto

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Ferruccio Ceriotti
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Matteo Vidali

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Via L. Temolo 4, 20126 Milano

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Giuseppe Agosta

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Chiara Riva
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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da M. Posadinu

Pemfigoide bolloso in una paziente di 106 anni
Bullous pemphigoid in a 106-years old female
V. Ventura  |  M. Posadinu  |  M. Deiana  |  A. Baralla  |  S. Pasella  |  L. Murgia  |  S. Pinna  |  E.  Canu  |  A. Zinellu  |  S. Sotgia  |  C. Carru  |  L. Deiana  | 
<p>Bullous pemhigoid (BP) is an autoimmune subepidermal blistering&nbsp;disease, usually occurring in the elderly. In Europe the incidence of BP has doubled in the last 10 years. The disease&nbsp;has a chronic relapsing course and a relatively benign prognosis. An increasing number of publications report altered&nbsp;expression of a number of cytokines. However, at the present it is not possible to establish a specific role for them in&nbsp;the disease. We report a case of a centenarian woman with a BP occurrence in otherwise optimal health conditions.&nbsp;Besides the usual biochemical investigations, plasma concentrations of a number of cytokines were evaluated during&nbsp;the disease course (relapse and remission). The majority of the measured cytokines were elevated in the active phase&nbsp;of the disease and returned to values similar to those presented by a group of apparently healthy subjects of similar&nbsp;age during the remission. This case could be useful to better understand the role of cytokines in autoimmune skin&nbsp;diseases of the aging.</p>
Biochimica Clinica ; 39(2) 152-156
Casi clinici - Case report