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Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

EIC Assistant
Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada

Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

Editorial Secretary
Chiara Riva
Biomedia srl
Via L. Temolo 4, 20126 Milano
Tel. 0245498282


ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da R. Pivonello

The improvement of oocyte selection for social freezing application
<p>Lifestyle, educational opportunities, career choices and new unions lead to pregnancy in more advanced age, increasing the emerging preventive solution to freeze oocytes at a young age for later use. In this scenario, the oocyte selection has a great importance in order to choose the best ones capable of a good subsequent embryo development and implantation. The aim of this study was to develop a decision support system, able to classify oocytes according to a score based on morphological features and patients&rsquo; clinical data. The approach would offer a more effective selection method because it is not dependent on the doctor&rsquo;s experience or on an &ldquo;at-first-sight&rdquo; impression. As a first step, a prototype system able to support embryologists in oocyte selection was presented and an experimental evaluation on a real set of data provided. The developed pipeline included the identification of main morphological features influencing oocyte quality and the assignment of a weight and of a better way of measuring them. After that, a standard data format collecting in an organized way all morphological features of oocytes, zigote and embryos and patients&rsquo; clinical data was developed. More than 150 oocytes images, taken in standard and comparable conditions, from 35 women were collected. Morphological features were extracted manually and automatically. A preliminary version of the scoring algorithm was tested on these data.</p>
Biochimica Clinica ; 41(4) 353-357
Contributi scientifici - Scientific papers
The role of the laboratory in the evaluation of male factor in couple infertility
<p>The evaluation of male factor in couple infertility aims at identifying risk factors and treatable causes of male infertility to offer an adequate counselling and to choose the best treatment options to improve fertility outcomes, including either the chance of a spontaneous conception or the outcome of assisted reproduction. The first approach to the infertile man requires an accurate assessment of medical history as well as a general and andrological anamnesis and physical examination. The evaluation is based on a series of laboratory procedures, comprising semen analysis, the assessment of hormone profile, the eventual microbiological tests for the investigation of urogenital tract infections and genetic testing. This is associated with scrotal ultrasound, aimed at investigating the structure of testis, funiculus, epididymis, vasa and pampiniform plexus, and transrectal ultrasound, aimed at providing information on prostate and seminal vesicles. Semen analysis, performed according to WHO 2010 guidelines, is fundamental to assess the male fertility potential. Hormone profile assessment evaluates the function of the hypothalamic-pituitarygonadal axis and is useful to establish a diagnosis of primary or secondary testis failure and to choose the most appropriate therapeutic approach. Microbiological assessment can be useful in case of clinical suspicion of urogenital tract infections, which might exert a detrimental effect on male fertility. Genetic testing, in particular karyotype analysis, and the assessment of Y chromosome microdeletions should be performed in case of clinical suspicion or in case of a severe reduction of sperm count.</p>
Biochimica Clinica ; 41(4) 335-345
Rassegne - Reviews