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Editor-in-chief
Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

EIC Assistant
Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada


Publisher
Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

Editorial Secretary
Chiara Riva
Biomedia srl
Via L. Temolo 4, 20126 Milano
Tel. 0245498282
email: biochimica.clinica@sibioc.it

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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091



BC: Articoli scritti da G. Petricciani

Titolazioni dei preparati galenici oleosi a base di cannabis in Regione Liguria: progetto sperimentale dei laboratori di riferimento regionale
Analysis of cannabinoids concentration in cannabis oil galenic preparations in the Liguria Region: experimental project of the regional reference laboratories
<p>Introduction: the medical use of cannabis is increasingly being applied in the treatment and support of several diseases and syndromes. In the Liguria Region, olive oil galenic preparations are mainly prepared by hospital pharmacies, according to common standard procedures. The preparations must be analyzed in order to establish the concentration of the two main active compounds (delta-9 tetrahydrocannabinol, THC and cannabidiol, CBD) thus allowing the correct setting of the therapeutic prescription. Liguria Region is at the forefront in the use of medical cannabis with a high number of patients treated (&gt;1000). The aim of this work is to describe the organization of the titration activity centralized at the two regional reference laboratories (Central Laboratory of Analyses of Giannina Gaslini Institute, Genova and Toxicology Laboratory of Sarzana, La Spezia), coordinated by the inter-hospital department (DIAR) of the Laboratories Area.<br />Methods: the phases of the analytical process (pre-analytical, analytical and post-analytical) have been identified and described. The analysis of the workflow has been carried out including the methods to prepare cannabis oil in the pharmacies, the intervals and production volumes, the medical-legal handling requirements and operational responsibilities. The definition of the pre-analytical phase foresees the methods of packaging, transport and recording of the samples and related responsibilities.<br />Results: the analytical phase included the development and validation of the analytical method Ultra High Performance Liquid Chromatography coupled to tandem mass spectrometry, (UHPLC-MS/MS) in the two laboratories, with common procedures and the comparison of results conducted both on reference material and real samples of olive oil galenic preparations. The definition of the post-analytical phase included the reporting procedures.<br />Discussion: the experimental phase has been concluded at the end of 2019 and the implementation phase of the project has started in march 2020.</p>
Biochimica Clinica ; 44(4) 367-373
Contributi Scientifici - Scientific Papers
 
Stato dell’arte delle analisi farmacotossicologiche nei laboratori di tossicologia italiani
State of the art of pharmacotoxicological analyses in Italian toxicology laboratories
<p>Analyses for drug and&nbsp;substance abuse represent a considerable part of the daily workload of pharmacotoxicology laboratories (PL).&nbsp;Lacking specific rules, PL have developed their own analytical drug testing procedures and, in turn, personalized&nbsp;reports and interpretation. In 2013, the SIBioC Toxicology Study Group did a national survey to assess the situation&nbsp;of the Italian PL involved in drug testing. Here data from this survey are reported. The survey included two&nbsp;questionnaires aimed to clarify laboratory procedures used for workplace drug and drug and alcohol on the road,&nbsp;respectively. The variability of qualitative variables was evaluated by the Gini index of heterogeneity. Although a low&nbsp;response rate to the survey (&lt;30 respondents), data clearly showed a high heterogeneity of laboratory procedures,&nbsp;including preanalytical (custody chain, methods of sample collection, sample volumes, sample adulteration check),&nbsp;analytical (instrumentations, methods, cut-offs) and post-analytical aspects (qualitative or quantitative reporting), in&nbsp;some cases even different from procedures required by Italian law, when available. To avoid subjective interpretation,&nbsp;which could lead to different treatments of citizens, an harmonization of analytical procedures used by the Italian PL&nbsp;is mandatory.</p>
Biochimica Clinica ; 39(2) 100-107
Contributi scientifici - Scientific Papers