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Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

EIC Assistant
Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada

Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

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Chiara Riva
Biomedia srl
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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da G. Perricone

Confronto tra marcatori sierici di fibrosi e biopsia epatica
A comparison between serum biomarkers of fibrosis and liver biopsy
<p>Hepatic fibrosis is a common response to&nbsp;prolonged liver injury and the liver biopsy is the standard method for assessing it. However, searching for alternative&nbsp;noninvasive approaches is important and immunoenzymatic assays using monoclonal antibodies have been recently&nbsp;developed to investigate the diagnostic utility of serum biomarkers. In this study, we explore the relationship between&nbsp;the grade of liver fibrosis and some biochemical parameters. We considered the following markers: collagen IV (CIV),&nbsp;coliglicin (CG), hyaluronic acid (HA), laminin (LN) and aminoterminal procollagen type III peptide (PIIIP). All markers&nbsp;were analyzed by new chemiluminescence immunoassays. We enrolled 36 patients with liver disease and available&nbsp;liver biopsy data. Furthermore, we compared the serum marker concentrations of patients with those of 16 healthy&nbsp;volunteers. Results showed a significant increase in concentrations of CIV, CG and PIIIP in patients with liver fibrosis.&nbsp;For CIV and PIIIP, a significant difference was also observed among groups with different fibrosis grade. In particular,&nbsp;a significant increase was evident in patients with early fibrosis when compared to patients without fibrosis.</p>
Biochimica Clinica ; 39(3) 188-192
Contributi scientifici - Scientific Papers