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Editor-in-chief
Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

EIC Assistant
Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada

Publisher
Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

Editorial Secretary
Chiara Riva
Biomedia srl
Via L. Temolo 4, 20126 Milano
Tel. 0245498282
email: biochimica.clinica@sibioc.it

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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da M. Pepe

A rare case of multiple alloantibody detection in a woman of childbearing age

M. Pepe \| E. Crollo \| A. Ostuni \|
<p><span style="color:#333333; font-family:arial,sans-serif; font-size:10.0pt">The Rhesus G antigen is expressed on C+ and D+ erythrocytes. As a consequence, anti-G antibodies can mimic the</span> presence of anti-C plus anti-D specificity on Indirect Antiglobulin Test . It is not possible to discriminate between the three antibodies in routine testing because anti-G can only be highlighted with the adsorption-elution test. During pregnancy, it is important to identify anti-G antibodies because their presence has been associated with hemolytic disease of the fetus and newborn (HDFN). It is also of fundamental importance to identify the antibodies really present because when anti-D is absent rhesus prophylaxis must be administered. The present case report describes the findings in a 44-yearold woman, who was group A Rh negative (phenotype ccdee), weak D negative; antibodies screening by Indirect Antigloblin Test (IAT) was positive. Antibody identification by IAT revealed anti-C, anti-D and anti-Jka antibodies. Due to the concomitant presence of anti-C and anti-D, the test for anti-G antibody was carried out by using adsorption-elution test. The results showed that in the patient’s blood anti-G, anti-C, anti-D and anti-Jka antibodies were present. This case report illustrates the usefulness of using manual methods together with the automated methods in the Immunohematology Laboratory. In fact, the simultaneous presence of anti-C and anti-D must always induce to check for the presence of anti-G which can be identified only with adsorption-elution methods.</p>
Biochimica Clinica ; 46(3) S141-S144 Casi Clinici - Case Report

Armonizzazione in Medicina di Laboratorio
Harmonization in Laboratory Medicine
F. Ceriotti \| M. Panteghini \| A. Tosetto \| V. Valentini \| L. Politi \| R. Rolla \| T. Guastafierro \| T. Köken \| E. Capoluongo \| C. Mazzaccara \| V. D'Argenio \| V. D'Argenio \| G. Lippi \| M. Plebani \| D. Giavarina \| M. Berardi \| A survey on sample matrix and preanalytical management in clinical laboratories \| D. Bozzato \| G. Messeri \| M. Zaninotto \| M. Vidali \| A. Padoan \| G. Parigi \| A. Clerico \| L. Sciacovelli \| M. Ciaccio \| G.L. Salvagno \| G. Barberio \| G. Barberio \| G.L. Salvagno \| M. Pepe \| M. Panteghini \| F. Braga \| G. Gessoni \| M. Montagnana \| N. Doğan \| M. Barberis \| M. Barberis \| A. Marchetti \| F. Borrillo \| L. Bonfanti \| P.M. Ness \| G. Messeri \| S. Nannini \| J. Queraltò \| M. Zaninotto \| A. Mosca \| BM. Henry \| G. Santini \| A. Coglianese \| V. D'Argenio \| E. Fiorio \| L. Crinò \| M. A. V. Willrich \| A. Modenese \| M. Berardi \| G. Nordera \| M. Girelli \| R. Tomaiuolo \| D. Giavarina \| R. Dittadi \| L. Pighi \| V. Guaraldo \| G. Bambagiotti \| R. Danesi \| M. Locatelli \| F. Balboni \| D. Cosseddu \| M. Savoia \| S. Bernardini \| C. Domenichini \| M. Lamonaca \| M. Perrone \| M. Perrone \| per il Gruppo di Studio Intersocietario SIBioC-SIPMeL Diabete Mellito \| P. Pradella \| A. Padoan \| M.T. Sandri \| L. Belloni \| A. D'Avolio \| T. Trenti \| A. Fortunato \| T. Trenti \|

Biochimica Clinica ; 39(6) 546-547 Editoriale - Editorial