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Maria Stella Graziani

Deputy Director
Martina Zaninotto

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Ferruccio Ceriotti
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Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
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Matteo Vidali

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Francesco Busardò

International Advisory Board Khosrow Adeli Canada
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Magdalena Krintus Poland
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Giuseppe Agosta

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Chiara Riva
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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da G. Pennesi

L’immunosottrazione può rivelarsi più utile dell’immunofissazione nella tipizzazione di componenti monoclonali IgAl
Immunosubtraction technique is sometimes more useful than immunofixation for typing IgAl monoclonal components
<p>The characterization of a monoclonal component involves a serum protein electrophoresis and the immunotyping. &nbsp;Serum samples from 6 patients showed a slight anomalous peak in the b-region of the serum electrophoresis. &nbsp;Using immunofixation, only a heavy chains were typed, suggesting an a heavy chain disease.&nbsp;In 4 of these cases, the problem was observed when the monoclonal component was detected for the first time, with a potential risk of misdiagnosis.&nbsp;The 4 cases account for 5% of new monoclonal component IgA detected in the considered period.&nbsp;Although there are several reports on the lower sensitivity of immunosubtraction in comparison with immunfixation, we report here some exceptions about the usefulness of immunosubtraction in the identification of small IgAl monoclonal components.</p>
Biochimica Clinica ; 39(5) 326-330
Contributi scientifici - Scientific Papers