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Editor-in-chief
Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

EIC Assistant
Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada

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Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

Editorial Secretary
Chiara Riva
Biomedia srl
Via L. Temolo 4, 20126 Milano
Tel. 0245498282
email: biochimica.clinica@sibioc.it

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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da G. Parigi

Emoglobina glicata (HbA1c): confronto tra gli analizzatori Premier Hb9210 e ADAMStm A1c HA-8180V
Glycated hemoglobin (HbA1c): Comparison between Premier Hb9210 and ADAMStm A1c HA-8180V analyzers
G. Parigi \| AL. Toni \| C. Scapellato \| M. Longini \|
<p>Introduction: in this study we evaluated the analytical performance of the Trinity Biotech HbPremier Hb9210 (Bray, Ireland/Kansas city, US), a boronate affinity chromatography-based high performance liquid chromatography (HPLC) system for the measurement of glycated hemoglobin. The ADAMSTM A1c HA-8180V (ARKRAY, Inc., Kyoto, Japan) analyzer was used for the comparison.<br />Methods: three pool of blood (L1, L2, L3) and two control materials (B1, B2) were used to evaluate analytical precision of the HbPremier Hb9210, analyzing five replicates of each sample per day for five days. For the comparison, blood specimens were analyzed according to the Clinical and Laboratory Standard Institute (CLSI) guidelines. Both the available reference systems (IFCC, NGSP) were used.<br />Results: the total CVs of for low, medium and high values of the three pools (L1, L2, L3) were 0.68%, 1.72%, 1.31% respectively; and were 1.57%, 1.38% for low, and medium values (B1, B2) of the two controls when the values were expressed in mmol/mol (SI units) and 0.39%, 1.18%, 1.08% (L1, L2, L3), 0.95%, 1.07% (B1, B2) when the values were reported in % (NGSP units). Passing-Bablok regression used for the comparison of methods showed a small proportional error (slope 1.05, 95%CI: 1.02-1.07) using the IFCC reference system (mmol/mol); the error was not present with the NGSP (%). The bias found was -1.87 mmol/mol (95%CI: -4.33- 0.58) and -0.17% (95%CI: -0.39-0.05).<br />Discussion: the analytical performances of HbPremier Hb9210 have been successfully verified. The instrument performs well and provides results in good agreement with those obtained with the ADAMS analyzer.</p>
Biochimica Clinica ; 46(1) 062-067 Contributi Scientifici - Scientific Papers

Armonizzazione in Medicina di Laboratorio
Harmonization in Laboratory Medicine
F. Ceriotti \| M. Panteghini \| A. Tosetto \| V. Valentini \| L. Politi \| R. Rolla \| T. Guastafierro \| T. Köken \| E. Capoluongo \| C. Mazzaccara \| V. D'Argenio \| V. D'Argenio \| G. Lippi \| M. Plebani \| D. Giavarina \| M. Berardi \| A survey on sample matrix and preanalytical management in clinical laboratories \| D. Bozzato \| G. Messeri \| M. Zaninotto \| M. Vidali \| A. Padoan \| G. Parigi \| A. Clerico \| L. Sciacovelli \| M. Ciaccio \| G.L. Salvagno \| G. Barberio \| G. Barberio \| G.L. Salvagno \| M. Pepe \| M. Panteghini \| F. Braga \| G. Gessoni \| M. Montagnana \| N. Doğan \| M. Barberis \| M. Barberis \| A. Marchetti \| F. Borrillo \| L. Bonfanti \| P.M. Ness \| G. Messeri \| S. Nannini \| J. Queraltò \| M. Zaninotto \| A. Mosca \| BM. Henry \| G. Santini \| A. Coglianese \| V. D'Argenio \| E. Fiorio \| L. Crinò \| M. A. V. Willrich \| A. Modenese \| M. Berardi \| G. Nordera \| M. Girelli \| R. Tomaiuolo \| D. Giavarina \| R. Dittadi \| L. Pighi \| V. Guaraldo \| G. Bambagiotti \| E. Franceschini \| R. Danesi \| M. Locatelli \| F. Balboni \| D. Cosseddu \| M. Savoia \| S. Bernardini \| C. Domenichini \| M. Lamonaca \| M. Perrone \| M. Perrone \| per il Gruppo di Studio Intersocietario SIBioC-SIPMeL Diabete Mellito \| P. Pradella \| A. Padoan \| M.T. Sandri \| L. Belloni \| A. D'Avolio \| T. Trenti \| A. Fortunato \| T. Trenti \|

Biochimica Clinica ; 39(6) 546-547 Editoriale - Editorial