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Maria Stella Graziani

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Giuseppe Agosta

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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da R.M. Paragliola

Valori falsamente elevati di triodotironina libera in una paziente affetta da tiroidite cronica e gozzo multinodulare
Falsely increased free triiodothyronine values in a woman affected by thyroiditis and multinodular goiter
<p>We&nbsp;describe a case of a 63-years old woman affected by Hashimoto&rsquo;s thyroiditis and multinodular goiter. Her laboratory&nbsp;results showed elevated free triiodothyronine (FT3) concentrations (18.5 ng/L), with free thyroxine (FT4) and&nbsp;thyrotropin (TSH) within the physiologic range. On the basis of these results, she started methimazole therapy, with&nbsp;persistence of inappropriately elevated FT3 concentrations. The therapy was thus stopped and blood examination&nbsp;was repeated after one month in our laboratory: concentrations of thyroid tests were within the physiologic range,&nbsp;including FT3 (2.8 ng/L). The difference between this result and that previously obtained raised the suspicion of the&nbsp;presence of an interference in the first result. In fact, in our laboratory a competitive electrochemiluminescence&nbsp;immunoassay with labeled antibody is used, while the first laboratory employed a competitive chemiluminescence&nbsp;immunoassay with labeled analogue, which has a more important risk of interference. After treating sample by&nbsp;polyethylene glycol, FT3 resulted indeed normal also by the immunoassay used by the first laboratory.</p>
Biochimica Clinica ; 38(1) 70-72
Casi clinici - Case report