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Editor-in-chief
Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

EIC Assistant
Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada


Publisher
Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

Editorial Secretary
Chiara Riva
Biomedia srl
Via L. Temolo 4, 20126 Milano
Tel. 0245498282
email: biochimica.clinica@sibioc.it

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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091



BC: Articoli scritti da M.C. Muzi

La metodica capillare per la misura della emoglobina glicata consente di rilevare varianti emoglobiniche
Capilalry mthod for measuring glycated hemoglobin allows the detection of hemoglobin variants
<p><span style="font-size:9pt">Diabetes mellitus is a worldwide disease and glycated hemoglobin (HbA</span><span style="font-size:5pt">1c</span><span style="font-size:9pt">) is the gold standard for the diagnosis and monitoring. Hemoglobin variants can interfere with HbA</span><span style="font-size:5pt">1c </span><span style="font-size:9pt">measurement in both preanalytical and analytical phases, and their incidental detection is continuously increasing, due to the recent migration waves. In the Roma 1 HUB Laboratory, HbA</span><span style="font-size:5pt">1c </span><span style="font-size:9pt">is measured by capillary electrophoresis (CE). A 51-year-old man from Bangladesh underwent HbA</span><span style="font-size:5pt">1c </span><span style="font-size:9pt">analysis and a variant was evident in the electrophoretic pattern. After informed consent for further analysis was given, a hemoglobin electrophoresis by CE was performed. A suspected HbE was found and then confirmed by molecular testing. The patient showed mild microcytosis and hypochromia, but no anemia. The presence of the variant HbE was without influence on HbA</span><span style="font-size:5pt">1c </span><span style="font-size:9pt">measurement by CE. This technique offers the advantage to detect hemoglobin variants as well as a reliable measurement of hemoglobin A</span><span style="font-size:5pt">2 </span><span style="font-size:9pt">(HbA</span><span style="font-size:5pt">2</span><span style="font-size:9pt">). These features allow a correct diagnosis of thalassemia and hemoglobinopathies without interfering with HbA</span><span style="font-size:5pt">1c </span><span style="font-size:9pt">measurement.</span></p>
Biochimica Clinica ; 46(3) e15-e17
Casi Clinici - Case Report