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Maria Stella Graziani

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Martina Zaninotto

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Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

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Francesco Busardò

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Giuseppe Agosta

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Chiara Riva
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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da M.G.L. Monaco

Stress ossidativo e broncopneumopatie professionali
Oxidative stress and professional pulmonary disease
<p>The chronic obstructive pulmonary disease (COPD) of&nbsp;occupational origin may be of functional, inflammatory or neoplastic nature and can also be caused by several&nbsp;chemical agents. One of the most risky processes of exposure to irritants for the respiratory system is welding, during&nbsp;which smoke and gases are released, with production of metal particulates and noxious gases, such as ozone,&nbsp;carbon monoxide, carbon dioxide and nitrogen oxide. The purpose of this study was to evaluate the reliability of the&nbsp;reactive oxygen metabolite assays in the early detection of professional COPD due to free radical damage, with the&nbsp;aim to identify markers whose measurements can be used in protocols of health surveillance of individuals exposed&nbsp;to fumes and noxious gases. The reactive oxygen metabolites were determined in serum of patients with a&nbsp;spectrophotometric procedure and obtained data were compared to those by the chemiluminescence produced by&nbsp;polymorphonuclear leukocytes (PMN) in the presence of luminol in whole blood samples. We enrolled 11 welders&nbsp;exposed to fumes and gases from the process of electric arc welding, 5 miners engaged in the extraction and&nbsp;processing of lava stone, 18 apparently healthy smokers not exposed to pollutants in their workplace and 20 healthy&nbsp;non-smokers not exposed to contaminants from work. Results showed that the spectrophotometric test is more&nbsp;reliable than the PMN activation test and can be used in the assessment of early damage by free radicals in&nbsp;professional COPD.</p>
Biochimica Clinica ; 38(1) 23-26
Contributi scientifici - Scientific papers