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Maria Stella Graziani

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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da A. Marchisio

Interleuchine e necrolisi tossica epidermica
Interleukins and toxic epidermal necrolysis (TEN)
V. Ventura  |  A. Posadinu  |  M. Deiana  |  A. Baralla  |  S. Pasella  |  L. Murgia  |  S. Pinna  |  E.  Canu  |  A. Marchisio  |  A. Zinellu  |  C. Carru  |  L. Deiana  | 
<p>TEN is a rare disease characterized by the separation of skin&nbsp;and mucous membranes from the derma. The reported clinical case refers to an adult female hospitalized at the&nbsp;Burns Unit after allopurinol prescription. During hospitalization the patient underwent the therapeutic protocol&nbsp;established at the Burns Unit including intravenus immunoglobulin administration and plasmapheresis. At the end of&nbsp;therapy a clinical improvement of both local and global conditions was observed. During the course of disease, we&nbsp;measured plasma concentrations of a number of cytokines. Measurements were performed using commercially&nbsp;available multiplex bead-based sandwich immunoassays (Biorad). We found a marked decrease in concentrations of&nbsp;interleukin (IL)-6, interferon -induced protein (IP)-10 e IL-13 at various stages of apheresis therapy, particularly&nbsp;pronounced for IP-10. We also found a normalization of IL-6 and IP-10 concentrations during the follow-up. In&nbsp;addition, very high concentrations of the same cytokines in the plasma effluent after apheresis were observed.&nbsp;Although obtained in a single case, our results suggest a correlation between plasma concentrations of cytokines and&nbsp;the clinical course of TEN. It can be postulated that this approach could serve as a guide for future research in the&nbsp;development of targeted therapy based on the etiopathogenesis of TEN.</p>
Biochimica Clinica ; 38(1) 65-69
Casi clinici - Case report