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Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

EIC Assistant
Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada

Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

Editorial Secretary
Chiara Riva
Biomedia srl
Via L. Temolo 4, 20126 Milano
Tel. 0245498282


ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da L. Marchioro

Sistema POCT per la determinazione su sangue intero della troponina cardiaca I ad alta sensibilità: quale valore nel territorio?
POCT system for the determination of high sensitivity cardiac troponin I: the value in the territory
<p>The Italian National Recovery and Resilience Plan (NRRP) provides resources for the activation for over a thousand Community Houses that will serve as permanent points of reference for the population with the aim to guarantee both the prevention activity and the&nbsp; care of patients. These structures need to be provided with Information Technology&nbsp; (essential for the implementation of telemedecine), an adequate multi-specialty instrumental equipment (radiology, clinical laboratory) and a multidisciplinary team of medical specialists, paediatricians, nurses and other health professionals. In this context, the clinical laboratory activity takes on a strategic role especially in the diagnosis of the acute miocardial damage (AMI) which is fundamentally based on the determination of Troponin I o T and no longer on instrumental investigations, such as ECG. High quality POCT devices are currently available on the market for the determination of Troponin I (and T) with high sensitivity methods characterized by adequate costs for the diagnostic efficacy they should guarantee. Recently, the POCT system QuidelTriage High Sensitivity Troponin I test has been evaluated&nbsp; using 75 whole blood samples from patients. Overall, the outcome of the trial was satisfactory and corresponded to the quality and performance specifications recommended by AACC and IFCC for a method that should assure&nbsp; an elevated level of diagnostic accuracy. The tested POCT device was effective in the management of patients with suspected AMI using either single cut-off value or 0/1 hour algorithm. This demonstrates the important contribution that POCT devices can offer for of early diagnosis and monitoring of chronic disease</p>
Biochimica Clinica ; 46(3) 241-246
Opinioni - Opinions
ISO 15189 all'ombra dell'Equatore. Descrizione dell’esperienza del North Kinangop Catholic Hospital Laboratory in Kenya
ISO 15189 in the shadow of the Equator. Description of the experience in the North Kinangop Catholic Hospital Laboratory (Kenya).
<p>Introduction: it is nowadays recognized that, in low income countries, the development of quality-assured laboratory services is a major part of a greater framework of health system strengthening and that limited laboratory capacity represents a major barrier to implementation and sustainability of prevention, treatment and care programs. Acknowledging this need, the North Kinangop Catholic Hospital clinical laboratory (Kenya) pursued and obtained ISO 15189 accreditation in clinical biochemistry and haematology.<br />Methods: the present paper describes the steps that led to this accomplishment in January 2019, as a result of a three-year project. Methodological support was provided by the School of Medicine (Maryland University, USA) as part of an American government program aimed to reinforce laboratory services in resource-poor countries. The iterative plan&ndash;do&ndash;check&ndash;act method was applied.<br />Results: major changes in laboratory management were introduced to meet the requirements of the standard. Analytical quality issues were reviewed; Internal Quality Control and External Quality Assessment procedures were implemented; reorganization of laboratory areas was made. The North Kinangop Catholic Hospital Laboratory obtained ISO 15189 accreditation in January 2019, as a result of a process started in March 2016.<br />Conclusions: a key to the success was professional commitment, sharing of values and external support, although careful planning resulted to be the key issue; actually, in low income countries social, political and even logistical peculiarities pose unique challenges.</p>
Biochimica Clinica ; 44(3) 239-248
Contributi Scientifici - Scientific Papers