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Editor-in-chief
Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

EIC Assistant
Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada


Publisher
Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

Editorial Secretary
Chiara Riva
Biomedia srl
Via L. Temolo 4, 20126 Milano
Tel. 0245498282
email: biochimica.clinica@sibioc.it

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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091



BC: Articoli scritti da M. Lamberti

Stress ossidativo e broncopneumopatie professionali
Oxidative stress and professional pulmonary disease
<p>The chronic obstructive pulmonary disease (COPD) of&nbsp;occupational origin may be of functional, inflammatory or neoplastic nature and can also be caused by several&nbsp;chemical agents. One of the most risky processes of exposure to irritants for the respiratory system is welding, during&nbsp;which smoke and gases are released, with production of metal particulates and noxious gases, such as ozone,&nbsp;carbon monoxide, carbon dioxide and nitrogen oxide. The purpose of this study was to evaluate the reliability of the&nbsp;reactive oxygen metabolite assays in the early detection of professional COPD due to free radical damage, with the&nbsp;aim to identify markers whose measurements can be used in protocols of health surveillance of individuals exposed&nbsp;to fumes and noxious gases. The reactive oxygen metabolites were determined in serum of patients with a&nbsp;spectrophotometric procedure and obtained data were compared to those by the chemiluminescence produced by&nbsp;polymorphonuclear leukocytes (PMN) in the presence of luminol in whole blood samples. We enrolled 11 welders&nbsp;exposed to fumes and gases from the process of electric arc welding, 5 miners engaged in the extraction and&nbsp;processing of lava stone, 18 apparently healthy smokers not exposed to pollutants in their workplace and 20 healthy&nbsp;non-smokers not exposed to contaminants from work. Results showed that the spectrophotometric test is more&nbsp;reliable than the PMN activation test and can be used in the assessment of early damage by free radicals in&nbsp;professional COPD.</p>
Biochimica Clinica ; 38(1) 23-26
Contributi scientifici - Scientific papers