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Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

EIC Assistant
Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
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Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

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Chiara Riva
Biomedia srl
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Tel. 0245498282


ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da P. Gori

Considerazioni sulle matrici biologiche idonee alla valutazione dell’“attualità d’uso di sostanze illecite” ai fini degli articoli 186 e 187 del nuovo Codice della Strada
Thoughts on biological matrices suitable for the assessment of "current use of illicit drugs" according to articles 186 and 187 of new Rules of the Road
R. Pacifici  |  P. Gori  |  L. Martucci  |  S. Pichini  | 
<p>Data on detection times of drugs of abuse in different biological&nbsp;matrices are based on pharmacokinetic studies in healthy volunteers during controlled clinical trials. The detection&nbsp;times mainly depend on the dose, route of administration, frequency of consumption (acute or chronic), detection limit&nbsp;of the assay employed for substance determination and matrix being analyzed (blood, saliva, urine, hair). Literature&nbsp;data agree that biologic effects drugs of abuse exert on the body match the presence of such substances and/or their&nbsp;metabolites in blood and/or saliva. Only after hepatic metabolism and renal excretion processes substances and/or&nbsp;their metabolites appear in urine, the last compartment from which substances are eliminated from the body. Hair&nbsp;analysis provides information on consumption of drugs of abuse in months prior to cutting of hair lock. These findings&nbsp;have relevance for the purposes of articles 186 and 187 of new Rules of the Road. Whereas in the case of alcohol,&nbsp;the law specifies in detail the biological matrix and the type of equipment to be used for the determination, for drugs&nbsp;of abuse it is unclear on what matrix is more appropriate to evaluate the presence of a substance of abuse and/or its&nbsp;metabolites in order to establish or better confirm driving under the influence of these substances. In this contribution,&nbsp;based on pharmacokinetic and pharmacodynamic considerations, we aim to reaffirm the most suitable biological&nbsp;matrices to determine the &quot;current use of illicit drugs&quot;.</p>
Biochimica Clinica ; 38(1) 27-31
Opinioni - Opinions