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Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

EIC Assistant
Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada

Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

Editorial Secretary
Chiara Riva
Biomedia srl
Via L. Temolo 4, 20126 Milano
Tel. 0245498282


ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da M. Giustiniano

1H NMR-based metabolomics study on follicular fluid from patients with Polycystic Ovary Syndrome
<p>Among reproductive-age women, polycystic ovary syndrome (PCOS) is a common endocrine disorder often associated with infertility and insulin resistance. Metabolomics studies on follicular fluid (FF) have shown to provide information about changes in the physiological state of patients as well as biomarkers for oocyte quality. In this context, we performed an exploratory NMR-based metabolomic study on FF samples provided from PCOS women that were undergoing an <em>in vitro</em> fertilization (IVF) therapy. We found that the hyperinsulinemia in PCOS patients is responsible for a different FF metabolic profile. In particular, hyperinsulinemia seems to be associated with impaired carbohydrate/glucose metabolism. Interestingly, plasma concentrations of Anti-M&uuml;llerian hormone (AMH) turned out to be positively correlated with glucose and negatively correlated with lactate, pyruvate and alanine. To the best of our knowledge, this is the first study that attempts to correlate AMH values with the FF metabolites. Although the data reported here are preliminary, this study paves the way to a better comprehension of the relationships among hormones and metabolites in FF.</p>
Biochimica Clinica ; 42(1) 26-31
Contributi scientifici - Scientific papers