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Editor-in-chief
Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

EIC Assistant
Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada


Publisher
Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

Editorial Secretary
Chiara Riva
Biomedia srl
Via L. Temolo 4, 20126 Milano
Tel. 0245498282
email: biochimica.clinica@sibioc.it

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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091



BC: Articoli scritti da A. Frezzotti

L’immunosottrazione può rivelarsi più utile dell’immunofissazione nella tipizzazione di componenti monoclonali IgAl
Immunosubtraction technique is sometimes more useful than immunofixation for typing IgAl monoclonal components
<p>The characterization of a monoclonal component involves a serum protein electrophoresis and the immunotyping. &nbsp;Serum samples from 6 patients showed a slight anomalous peak in the b-region of the serum electrophoresis. &nbsp;Using immunofixation, only a heavy chains were typed, suggesting an a heavy chain disease.&nbsp;In 4 of these cases, the problem was observed when the monoclonal component was detected for the first time, with a potential risk of misdiagnosis.&nbsp;The 4 cases account for 5% of new monoclonal component IgA detected in the considered period.&nbsp;Although there are several reports on the lower sensitivity of immunosubtraction in comparison with immunfixation, we report here some exceptions about the usefulness of immunosubtraction in the identification of small IgAl monoclonal components.</p>
Biochimica Clinica ; 39(5) 326-330
Contributi scientifici - Scientific Papers
 
Prevalenza di componenti monoclonali in una popolazione di donatori di sangue
Prevalence of monoclonal components in a blood donor population
<p>Occasional detection of monoclonal&nbsp;components (MC) is frequently attributable to the clinically silent presence of monoclonal gammopathy of&nbsp;undetermined significance, which nevertheless carries a small risk of developing into myeloma over the years. Over&nbsp;2007-2012, 9902 blood donors underwent serum protein electrophoresis (SPE) during routine blood tests. Any&nbsp;abnormalities in their SPE pattern were confirmed and characterized by serum protein immunofixation (IFE). A MC&nbsp;was detected in 58 donors (0.59%), the frequency being significantly higher in males (56/6564) than in females&nbsp;(2/3338) (P &lt;0.0001). There was a 2.2% prevalence in individuals &gt;50 years. The monoclonal immunoglobulins were&nbsp;IgG (70.7%), IgM (15.5%), IgA (12.1%) and IgD (1.7%). The involved light chains were <span style="font-family:symbol">k</span> in 67.2% and<span style="font-family:symbol"> l</span> in 32.8% of&nbsp;cases. The Bence-Jones protein test was always negative in 18 examined cases. The prevalence of MC in individuals&nbsp;&gt;50 years was similar to that reported in other studies and higher than that reported in the &rsquo;70-&rsquo;80s. These findings&nbsp;may indicate a potential increase in the number of myeloma cases.</p>
Biochimica Clinica ; 38(4) 292-294
Contributi scientifici - Scientific Papers
 
Un caso di mieloma IgDk
The IgDk myeloma: a case report
Biochimica Clinica ; 36(6) 441-442
Lettere all'Editore - Letters to the Editor