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Editor-in-chief
Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

EIC Assistant
Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada

Publisher
Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

Editorial Secretary
Chiara Riva
Biomedia srl
Via L. Temolo 4, 20126 Milano
Tel. 0245498282
email: biochimica.clinica@sibioc.it

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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da R. Facchinetti

Dabigatran e analisi di laboratorio
Dabigatran and laboratory tests
R. Facchinetti \| B. Capizzi \| B. Caruso \| M. Negri \| R. Suppi \| G. Molon \| G.C. Guidi \|
<p>New oral anticoagulants (i.e., dabigatran, rivaroxaban, apixaban) are now available. In using these drugs, routine monitoring of laboratory coagulation tests is not recommended. In some clinical conditions, however, a laboratory evaluation of hemostatic balance may be useful. Tests suggested for laboratory monitoring of dabigatran treatment are thrombin time on undiluted (TT) or diluted (dTT) plasma and ecarin clotting time. On 30 patients taking dabigatran for non valvular atrial fibrillation, we assayed dabigatran levels by dTT, also performing prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen and TT. In patients taking dabigatran etexilate 110 mg bis in die and 150 mg bis in die, dTT mean results (10<sup>th</sup>-90<sup>th</sup> percentile) were 97 (32-152) and 94 (33-189) μg/L, respectively. In dTT range from 13 to 60 μg/L and >60 μg/L, we obtained 27% and 58% prolonged PT, 64% and 95% prolonged APTT, and 100% and 100% prolonged TT, respectively, showing that for dabigatran TT is a useful screening test.</p>
Biochimica Clinica ; 39(1) 041-047 Contributi scientifici - Scientific Papers

Utilità della misura dell’attività plasmatica di eparina-anti fattore Xa durante trattamento antitrombotico in gravidanza
Usefulness of heparin-anti factor Xa assay during antithrombotic treatment in pregnancy
R. Facchinetti \|
<p>A case of successful pregnancy in a woman with previous episodes of unprovoked deep vein thrombosis treated with vitamin K antagonist (warfarin) therapy is described. As the patient became pregnant, warfarin therapy was immediately stopped and lowmolecular-weight heparin (LMWH) prophylaxis was started. In the second and third trimesters of pregnancy we observed an increase in body weight (from 64 to 80 kg) and in body mass index (from 21 to 26.4). During the pregnancy, we used the heparin-anti factor Xa assay (Anti-FXa) to monitor the LMWH treatment and to adjust the dosage in a increasing way. The Anti-FXa can be very useful in improving safety and efficacy of LMWH treatment in pregnancy.</p>
Biochimica Clinica ; 37(6) 504-507 Casi clinici - Case report

Esperienza pilota di accreditamento di un centro per la diagnosi della trombosi e la sorveglianza delle terapie antitrombotiche
A pilot accreditation experience of a thrombosis center
R. Facchinetti \| B. Capizzi \| M. Negri \| R. Suppi \| M.S. Graziani \|
<p>This paper describes the process of the accreditation of our Thrombosis Center by the Italian Federation of Thrombosis Centers (FCSA). The experience is reported, describing in details the organizational and clinical standard requirements and emphasizing foreseeable benefits and expectations for patients, operators, hospital, and health service.</p>
Biochimica Clinica ; 36(2) 090-097 Contributi Scientifici - Scientific Papers