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Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

EIC Assistant
Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada

Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

Editorial Secretary
Chiara Riva
Biomedia srl
Via L. Temolo 4, 20126 Milano
Tel. 0245498282


ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da M. Di Benedetto

Sinergia tra esperienza dell’operatore e analizzatori del sedimento urinario nella diagnosi di infezione da Poliomavirus BK
Laboratory professional and urinary sediment analyzer for the diagnosis of Polyomavirus BK infection.
<p>Laboratory professional and urinary sediment analyzer for the diagnosis of Polyomavirus BK infection. Polyomavirus BK (BKV)-infected cells, (the so called decoy cells) were observed in two solid organ (kidney and lung) transplant recipients. In both patients, serum creatinine and BKV viremia were increased. Pharmacological immunodepression, during the 3-6 month period after transplantation, increases the risk of this viral infection and the related BKV nephropathy. Sedimax (Menarini), the automatic urinary sediment analyzer equipped with instrumental filters to select specific cellular patterns, utilized in our laboratory for urine examination, recognized some elements with enlarged ground glass&ndash;like nucleus and flagged them as &quot;non-squamous epithelial cells&quot;. By using a phase contrast microscopy, we re-analyzed these specific urinary samples and identified these elements as decoy cells. Serial urinary sediment analysis is strictly required both to search early infection signs and to switch the differential diagnosis from neoplastic to BKV-infected cells. These crucial findings, provided by the laboratory staff expertise, can accelerate clinical decisions improving thus the long term transplantation outcomes.</p>
Biochimica Clinica ; 42(4) e50-e52
Casi Clinici - Case Report