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Maria Stella Graziani

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Martina Zaninotto

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Ferruccio Ceriotti
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Matteo Vidali

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Giuseppe Agosta

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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da C. Codazzo

La metodica capillare per la misura della emoglobina glicata consente di rilevare varianti emoglobiniche
Capilalry mthod for measuring glycated hemoglobin allows the detection of hemoglobin variants
<p><span style="font-size:9pt">Diabetes mellitus is a worldwide disease and glycated hemoglobin (HbA</span><span style="font-size:5pt">1c</span><span style="font-size:9pt">) is the gold standard for the diagnosis and monitoring. Hemoglobin variants can interfere with HbA</span><span style="font-size:5pt">1c </span><span style="font-size:9pt">measurement in both preanalytical and analytical phases, and their incidental detection is continuously increasing, due to the recent migration waves. In the Roma 1 HUB Laboratory, HbA</span><span style="font-size:5pt">1c </span><span style="font-size:9pt">is measured by capillary electrophoresis (CE). A 51-year-old man from Bangladesh underwent HbA</span><span style="font-size:5pt">1c </span><span style="font-size:9pt">analysis and a variant was evident in the electrophoretic pattern. After informed consent for further analysis was given, a hemoglobin electrophoresis by CE was performed. A suspected HbE was found and then confirmed by molecular testing. The patient showed mild microcytosis and hypochromia, but no anemia. The presence of the variant HbE was without influence on HbA</span><span style="font-size:5pt">1c </span><span style="font-size:9pt">measurement by CE. This technique offers the advantage to detect hemoglobin variants as well as a reliable measurement of hemoglobin A</span><span style="font-size:5pt">2 </span><span style="font-size:9pt">(HbA</span><span style="font-size:5pt">2</span><span style="font-size:9pt">). These features allow a correct diagnosis of thalassemia and hemoglobinopathies without interfering with HbA</span><span style="font-size:5pt">1c </span><span style="font-size:9pt">measurement.</span></p>
Biochimica Clinica ; 46(3) e15-e17
Casi Clinici - Case Report