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Editor-in-chief
Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

EIC Assistant
Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada

Publisher
Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

Editorial Secretary
Chiara Riva
Biomedia srl
Via L. Temolo 4, 20126 Milano
Tel. 0245498282
email: biochimica.clinica@sibioc.it

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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da F. Cocci

Valore predittivo della determinazione di neutrofili e granulociti immaturi nel sangue periferico per il rischio di mortalità in soggetti con patologie cardiopolmonari
Predictive value of the neutrophil and immature granulocyte blood counts for the mortality risk in subjects with cardiopulmonary disease
A. Papa \| C. Bauleo \| M. Fornaro \| F. Cocci \|
<p> An increase in the peripheral blood of immature granulocytes (IG) provides information on enhanced bone marrow activity and has been shown to be useful as predictor of infection and sepsis both in adults and pediatric subjects. The association between an elevated neutrophil count (NEU) and risk for cardiac and overall mortality has yet been proven, but in hospitalized adult patients the contribution of IG to prediction of death remains to be clarified. The aim of this study was to retrospectively evaluate the admission complete blood count and white blood cell differential generated with a Cell-Dyn Sapphire analyzer (Abbott Diagnostics) from 139 patients affected by cardiac and/or pulmonary disease. Patients were divided into 3 groups: group A (controls) consisted of 40 patients with NEU and IG within reference limits; group B included 47 subjects with an increased NEU, but physiological values of IG; group C was formed of 52 patients with neutrophilia combined with elevated IG. The median neutrophil count and IG of group C were 16.56x10<sup>9</sup>/L [interquartile range (IQR): 11.01-21.87] and 6.2% (IQR: 4.2-9.9), respectively. At multivariate analysis, IG emerged as the best predictor of 24-month mortality (hazard ratio, 2.62; P=0.006). Kaplan-Meier analysis showed a significant worsening in the survival of patients with presence of IG during hospitalization (87.2%, 71.2% and 41.9% for A, B and C group, respectively). Elevated NEU and IG predict future adverse events in cardiopulmonary patients and might be included in a risk prediction algorithm.</p>
Biochimica Clinica ; 40(3) 225-228 Contributi scientifici - Scientific Papers

Armonizzazione del referto ematologico con l’impego di unità di misura conformi al Sistema Internazionale
Harmonization of the hematology test report by using units according to the International System (SI)
A. Papa \| S. Buoro \| A. Marini \| F. Balboni \| A. Fanelli \| G. Da Rin \| A. Di Fabio \| S. Francione \| M. Gioia \| S. Pipitone \| D. Tanca \| F. Fiorini \| V. Rocco \| F. Cocci \| A. La Gioia \| Gruppo di Studio SIBioC - Medicina di Laboratorio Diagnostica ematologica \|
<p>The need for harmonizing hematology reporting units remains an important challenge for the clinical laboratory community. In 2014, the SIBioC Diagnostic Hematology Study Group (GdS-DE) carried out a survey to assess the state-of-the-art of the Italian hematology laboratories. The survey showed that the majority of laboratories report results using units of measurement that do not conform to SI. In some European countries, initiatives to harmonize hematology reporting units were taken some years ago. In particular, in the UK for the reporting of laboratory hematology results the SI units have been used since April 2013 (this includes hemoglobin and mean corpuscular hemoglobin concentrations in g/L). The aim of this GdS-DE proposal is to advocate a national initiative for promoting the adoption of SI units for hematology reporting. This will optimise the comparability of results among different laboratories and prevent the misinterpretation of data, which may worsen the patient's outcome.</p>
Biochimica Clinica ; 39(6) 627-630 Opinioni - Opinions