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Maria Stella Graziani

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Martina Zaninotto

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Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

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Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
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Ana-Maria Simundic Croatia
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Giuseppe Agosta

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Chiara Riva
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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da F. Cocci

Valore predittivo della determinazione di neutrofili e granulociti immaturi nel sangue periferico per il rischio di mortalità in soggetti con patologie cardiopolmonari
Predictive value of the neutrophil and immature granulocyte blood counts for the mortality risk in subjects with cardiopulmonary disease
A. Papa  |  C. Bauleo  |  M. Fornaro  |  F. Cocci  | 
<p>&nbsp;An increase in the peripheral blood of immature granulocytes (IG) provides&nbsp;information on enhanced bone marrow activity and has been shown to be useful as predictor of infection and sepsis&nbsp;both in adults and pediatric subjects. The association between an elevated neutrophil count (NEU) and risk for cardiac&nbsp;and overall mortality has yet been proven, but in hospitalized adult patients the contribution of IG to prediction of&nbsp;death remains to be clarified. The aim of this study was to retrospectively evaluate the admission complete blood&nbsp;count and white blood cell differential generated with a Cell-Dyn Sapphire analyzer (Abbott Diagnostics) from 139&nbsp;patients affected by cardiac and/or pulmonary disease. Patients were divided into 3 groups: group A (controls)&nbsp;consisted of 40 patients with NEU and IG within reference limits; group B included 47 subjects with an increased&nbsp;NEU, but physiological values of IG; group C was formed of 52 patients with neutrophilia combined with elevated IG.&nbsp;The median neutrophil count and IG of group C were 16.56x10<sup>9</sup>/L [interquartile range (IQR): 11.01-21.87] and 6.2%&nbsp;(IQR: 4.2-9.9), respectively. At multivariate analysis, IG emerged as the best predictor of 24-month mortality (hazard&nbsp;ratio, 2.62; P=0.006). Kaplan-Meier analysis showed a significant worsening in the survival of patients with presence&nbsp;of IG during hospitalization (87.2%, 71.2% and 41.9% for A, B and C group, respectively). Elevated NEU and IG&nbsp;predict future adverse events in cardiopulmonary patients and might be included in a risk prediction algorithm.</p>
Biochimica Clinica ; 40(3) 225-228
Contributi scientifici - Scientific Papers
Armonizzazione del referto ematologico con l’impego di unità di misura conformi al Sistema Internazionale
Harmonization of the hematology test report by using units according to the International System (SI)
<p>The&nbsp;need for harmonizing hematology reporting units remains an important challenge for the clinical laboratory community.&nbsp;In 2014, the SIBioC Diagnostic Hematology Study Group (GdS-DE) carried out a survey to assess the state-of-the-art&nbsp;of the Italian hematology laboratories. The survey showed that the majority of laboratories report results using units of&nbsp;measurement that do not conform to SI. In some European countries, initiatives to harmonize hematology reporting&nbsp;units were taken some years ago. In particular, in the UK for the reporting of laboratory hematology results the SI units&nbsp;have been used since April 2013 (this includes hemoglobin and mean corpuscular hemoglobin concentrations in g/L).&nbsp;The aim of this GdS-DE proposal is to advocate a national initiative for promoting the adoption of SI units for&nbsp;hematology reporting. This will optimise the comparability of results among different laboratories and prevent the&nbsp;misinterpretation of data, which may worsen the patient&#39;s outcome.</p>
Biochimica Clinica ; 39(6) 627-630
Opinioni - Opinions