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Maria Stella Graziani

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Martina Zaninotto

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Ferruccio Ceriotti
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Giuseppe Agosta

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Chiara Riva
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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da A. Carbucicchio

Proteina S100B ed enolasi neurone-specifica nella valutazione iniziale del trauma cranico lieve nell’adulto: pronte per il debutto nel mondo reale?
Protein S100B and neuron-specific enolase (NSE) for the initial evaluation of mild head trauma in adults: ready for prime time?
<p>Computerized tomography (CT) remains the best option for diagnosis of head trauma,&nbsp;although it carries several drawbacks. Among a large number of putative biomarkers proposed for initial evaluation&nbsp;of mild head trauma, protein S100B and NSE exhibit the best diagnostic performance. We performed a prospective&nbsp;study, where these biomarkers were assessed in 68 patients consecutively admitted to the Emergency Department&nbsp;(ED) with mild head trauma. The CT scan revealed brain lesions in 11 patients (16%). Concentrations of both&nbsp;biomarkers in serum were found to be more elevated in patients with positive CT than in those with negative scans.&nbsp;The area under the ROC curve (AUC) of protein S100B (0.89, 95% confidence interval: 0.81-0.97) was, however,&nbsp;significantly greater than that of NSE (0.77, 95% confidence interval: 0.64-0.90) (P=0.044). It was estimated that&nbsp;determination of protein S100B in all patients presenting to the ED with mild head trauma could safely save up to 50%&nbsp;CT execution, reducing the overall healthcare expenditure by ~1/3.</p>
Biochimica Clinica ; 38(3) 227-233
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