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Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

EIC Assistant
Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada

Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

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Chiara Riva
Biomedia srl
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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da A. Camerotto

Il “software” GOELM come innovativa modalità di gestione della conoscenza e della prescrizione degli esami di laboratorio: l’esperienza di due Unità Sociosanitarie Locali
The software GOELM as an innovative way of knowledge management and prescription of laboratory tests:the experience of two Local Healthcare Units (ULSS).
<p>Laboratory tests play a pivotal role in the diagnostic process. Unfortunately, their usefulness is undermined by a substantial proportion of inappropriateness. Up to now the employed strategies appear inadequate to solve the problem. This study presents a structural solution based on health information technology. In 2008 and 2010, an innovative way for prescribing laboratory tests was tested with the help of general practitioners of ULSS 18 Rovigo and ULSS 13 Mirano. It uses a software called GOELM (Guide Order Entry Laboratory Medicine). During the order entry, the software proposes indications about the clinical use of the laboratory test in real time. The general practitioner could accept or not the indication. The number of prescriptions formulated with the use of GOELM was compared with the number of prescriptions formulated by the same doctors without GOELM in the same period of the previous year. Our results demonstrate that the use of GOELM software<br />has achieved a reduction in the total number of prescriptions up to 38% in Rovigo and up to 26% in Mirano. This trial demonstrates that it is possible to make governance in prescription without political and/or administrative measures. GOELM was therefore proved effective in reducing the inappropriateness through knowledge management.</p>
Biochimica Clinica ; 36(2) 098-106
Studio sulla presenza di componenti monoclonali in pazienti con infezione da SARS-CoV-2: dati preliminari
Presence of monoclonal components in SARS-CoV-2 patients: preliminary data
<p>Introduction: electrophoresis of serum proteins (EF) is indicated for the identification and monitoring of monoclonal components (CM). It has been shown that interleukins play a role in the differentiation of B cells in plasma cells producing immunoglobulins; it has been also demonstrated that COVID-19 patients show a higher prevalence of CM in comparison to the general population. The aim of this work is to retrospectively evaluate the presence of CM in patients hospitalized with COVID-19, compared to a population of patients admitted in non-COVID-19 wards.<br />Methods: EF was performed in the two groups of patients (COVID positive and negative) using capillary electrophoresis. Patients with previous plasma cell dyscrasias have been excluded.<br />Results: the results show that in the COVID positive group, the incidence of CM is statistically higher compared to the COVID negative group (39.7% versus 13.3%). In one patient, the CM was no longer detectable when the swab became negative.<br />Conclusions: the study confirmed that the viral infection produces detectable CM, probably transitory as shown by a case index. The pathogenesis of the phenomenon could be explained by the cytokine stimulus on B cells and by the interaction of the virus with the lymphocyte ACE 2 receptor. Larger studies are needed to confirm the presented data.</p>
Biochimica Clinica ; 17(1)
Contributi Scientifici - Scientific Papers