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Editor-in-chief
Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

EIC Assistant
Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada

Publisher
Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

Editorial Secretary
Chiara Riva
Biomedia srl
Via L. Temolo 4, 20126 Milano
Tel. 0245498282
email: biochimica.clinica@sibioc.it

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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da V. Bianchi

In ricordo di Jan-Olof Jeppsson

A. Mosca \| V. Bianchi \|

Biochimica Clinica ; 44(3) 320 Notizie SIBioC - SIBioC News

Transferrina carboidrato-carente e abuso alcolico
Carbohydrate-deficient transferrin (CDT) and heavy alcohol consumption
V. Bianchi \|
<p>Alcohol abuse is an important social problem potentially leading to isolation, physical consequences and severe pathologies. Alcohol intoxication is correlated to car accidents, injuries and violence. Developing effective strategies to prevent, diagnose and treat alcohol abuse is therefore a social and medical priority. CDT is considered the most specific biomarker of chronic alcohol abuse. In this review, after a short introduction on CDT biochemistry and metabolism, pre-analytical, analytical and post-analytical phases of its measurement are discussed. Given the availability of several methods to measure CDT, including HPLC, capillary electrophoresis and immunoassays, their analytical performances are briefly summarized. The lack of CDT standardization led to the creation of a working group under the IFCC to define the target analyte, select and validate a reference method and establish procedures for the production of reference materials. Preliminary results and critical problems related to the standardization process are discussed. Finally, sensitivity and specificity of CDT to detect heavy alcohol intake, cut-off estimate and data interpretation are reviewed.</p>
Biochimica Clinica ; 39(1) 017-024 Rassegne - Reviews