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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da V. Bianchi

In ricordo di Jan-Olof Jeppsson
A. Mosca  |  V. Bianchi  | 
Biochimica Clinica ; 44(3) 320
Notizie SIBioC - SIBioC News
Transferrina carboidrato-carente e abuso alcolico
Carbohydrate-deficient transferrin (CDT) and heavy alcohol consumption
V. Bianchi  | 
<p>Alcohol abuse is an important social&nbsp;problem potentially leading to isolation, physical consequences and severe pathologies. Alcohol intoxication is&nbsp;correlated to car accidents, injuries and violence. Developing effective strategies to prevent, diagnose and treat&nbsp;alcohol abuse is therefore a social and medical priority. CDT is considered the most specific biomarker of chronic&nbsp;alcohol abuse. In this review, after a short introduction on CDT biochemistry and metabolism, pre-analytical, analytical&nbsp;and post-analytical phases of its measurement are discussed. Given the availability of several methods to measure&nbsp;CDT, including HPLC, capillary electrophoresis and immunoassays, their analytical performances are briefly&nbsp;summarized. The lack of CDT standardization led to the creation of a working group under the IFCC to define the&nbsp;target analyte, select and validate a reference method and establish procedures for the production of reference&nbsp;materials. Preliminary results and critical problems related to the standardization process are discussed. Finally,&nbsp;sensitivity and specificity of CDT to detect heavy alcohol intake, cut-off estimate and data interpretation are reviewed.</p>
Biochimica Clinica ; 39(1) 017-024
Rassegne - Reviews