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Editor-in-chief
Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

EIC Assistant
Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada

Publisher
Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

Editorial Secretary
Chiara Riva
Biomedia srl
Via L. Temolo 4, 20126 Milano
Tel. 0245498282
email: biochimica.clinica@sibioc.it

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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da R. Berni Canani

Meccanismi epigenetici nella patogenesi dell’allergia al latte vaccino
Epigenetics and cow’s milk allergy: implication for pathogenesis
F.D.E. De Palma \| L. Paparo \| R. Nocerino \| R. Berni Canani \| F. Salvatore \| V. D'Argenio \|
<p>Cows’ milk allergy (CMA) is one of the most frequent allergies in child, often occurring quite soon after birth. Recent years have been featured by an increasing prevalence of CMA that can often be the first appearance of the so-called “atopic march”. Typically, CMA is featured by immunoglobulin E (IgE)-mediated reactions; however, the pathogenetic basis of IgE-mediated CMA is not yet completely understood. Recent evidences suggest that epigenetic factors, such as DNA methylation and regulatory non-coding RNAs could play a role in allergic diseases, including CMA. Here, we review the state of the art regarding the involvement of some epigenetic modifications in allergic diseases, and especially in CMA. We describe that epigenetic derived molecules, in addition to be pathogenetic factors contributing to typical CMA allergic phenomena, could also serve to produce molecules which may act as novel, specific and easily accessible biomarkers for CMA diagnosis and monitoring.</p>
Biochimica Clinica ; 42(2) 103-111 Rassegne - Reviews