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Maria Stella Graziani

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Giuseppe Agosta

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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da C. Bauleo

Valore predittivo della determinazione di neutrofili e granulociti immaturi nel sangue periferico per il rischio di mortalità in soggetti con patologie cardiopolmonari
Predictive value of the neutrophil and immature granulocyte blood counts for the mortality risk in subjects with cardiopulmonary disease
A. Papa  |  C. Bauleo  |  M. Fornaro  |  F. Cocci  | 
<p>&nbsp;An increase in the peripheral blood of immature granulocytes (IG) provides&nbsp;information on enhanced bone marrow activity and has been shown to be useful as predictor of infection and sepsis&nbsp;both in adults and pediatric subjects. The association between an elevated neutrophil count (NEU) and risk for cardiac&nbsp;and overall mortality has yet been proven, but in hospitalized adult patients the contribution of IG to prediction of&nbsp;death remains to be clarified. The aim of this study was to retrospectively evaluate the admission complete blood&nbsp;count and white blood cell differential generated with a Cell-Dyn Sapphire analyzer (Abbott Diagnostics) from 139&nbsp;patients affected by cardiac and/or pulmonary disease. Patients were divided into 3 groups: group A (controls)&nbsp;consisted of 40 patients with NEU and IG within reference limits; group B included 47 subjects with an increased&nbsp;NEU, but physiological values of IG; group C was formed of 52 patients with neutrophilia combined with elevated IG.&nbsp;The median neutrophil count and IG of group C were 16.56x10<sup>9</sup>/L [interquartile range (IQR): 11.01-21.87] and 6.2%&nbsp;(IQR: 4.2-9.9), respectively. At multivariate analysis, IG emerged as the best predictor of 24-month mortality (hazard&nbsp;ratio, 2.62; P=0.006). Kaplan-Meier analysis showed a significant worsening in the survival of patients with presence&nbsp;of IG during hospitalization (87.2%, 71.2% and 41.9% for A, B and C group, respectively). Elevated NEU and IG&nbsp;predict future adverse events in cardiopulmonary patients and might be included in a risk prediction algorithm.</p>
Biochimica Clinica ; 40(3) 225-228
Contributi scientifici - Scientific Papers