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Editor-in-chief
Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

EIC Assistant
Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada

Publisher
Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

Editorial Secretary
Chiara Riva
Biomedia srl
Via L. Temolo 4, 20126 Milano
Tel. 0245498282
email: biochimica.clinica@sibioc.it

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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da S. Baggio

Caso atipico di orticaria
A case of atypical urticaria
M. Marinova \| M. Nabergoj \| C. Artusi \| S. Baggio \| L. Brugnolo \| M. Zaninotto \| M. Plebani \|
<p>Adult onset Still’s disease (AOSD) is a rare clinical entity with unknown etiology and pathogenesis, characterized by high spiking fevers, arthritis, typical evanescent, nonpruritic, macular and salmon<br />coloured rash, and multiorgan involvement. AOSD remains a diagnostic challenge due to the overlapping features with numerous infective, neoplastic and rheumatological conditions. A case of AOSD with atypical cutaneous manifestations in a 50-year-old female is reported. The patient’s symptoms included: remittent fever, widespread urticarial, maculopapular erythema and a sore throat. Hematological investigations showed leukocytosis with neutrophilia. There were markedly elevated levels of serum ferritin (20.920 μg/L) and mild liver dysfunction. A glycosylated ferritin assay was performed because of a severe hyperferritinemia, showing a reduction of the glycosylated fraction (<20%), a newly proposed diagnostic criteria for AOSD. We emphasize the diagnostic value of low glycosylated ferritin concentration for the differential diagnosis of this rare disease, particularly in case of atypical presentation.</p>
Biochimica Clinica ; 39(5) e10-e12 Casi clinici - Case report