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Editor-in-chief
Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

EIC Assistant
Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada

Publisher
Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

Editorial Secretary
Chiara Riva
Biomedia srl
Via L. Temolo 4, 20126 Milano
Tel. 0245498282
email: biochimica.clinica@sibioc.it

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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da L. Anemona

Ferritina e siderofagi liquorali nella diagnosi di siderosi cerebrale superficiale
Cerebrospinal fluid ferritin and siderophages in the diagnosis of superficial cerebral siderosis
G.M. Sancesario \| T. Schirinzi \| L. Anemona \| A. Pisani \| O. Porzio \| G. Sancesario \| S. Bernardini \|
<p>We observed a case of superficial siderosis (SS) of the central nervous system caused by an hemorrhagic trauma forty years before. We questioned whether SS was the stabilized effect of a remote bleeding or an evolutionary process indirectly related to the trauma. Moreover, we aimed to evaluate whether an iron chelator can affect the level of iron deposition. Magnetic Resonance (MRI) demonstrated iron accumulation mainly on the surface of the cerebellum and brain stem. Cerebrospinal fluid (CSF) microscopic analysis revealed few siderophages; CSF ferritin level was 76 ng/mL (reference value <12). After treatment with an iron chelator (deferiprone) for three months, MRI was unchanged, but the CSF ferritin was about 20% less. The presence of few siderophages supported the hypothesis of a persistent subarachnoid microbleeding. CSF ferritin, as an iron deposition index, allowed a diagnosis of SS and a<br />more sensitive evaluation of the efficacy of the treatment than the MRI.</p>
Biochimica Clinica ; 39(6) e19-e21 Casi clinici - Case report