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Editor-in-chief
Maria Stella Graziani

Deputy Director
Martina Zaninotto

Associate Editors
Ferruccio Ceriotti
Davide Giavarina
Bruna Lo Sasso
Giampaolo Merlini
Martina Montagnana
Andrea Mosca
Paola Pezzati
Rossella Tomaiuolo
Matteo Vidali

EIC Assistant
Francesco Busardò

International Advisory Board Khosrow Adeli Canada
Sergio Bernardini Italy
Marcello Ciaccio Italy
Eleftherios Diamandis Canada
Philippe Gillery France
Kjell Grankvist Sweden
Hans Jacobs The Netherlands
Eric Kilpatrick UK
Magdalena Krintus Poland
Giuseppe Lippi Italy
Mario Plebani Italy
Sverre Sandberg Norway
Ana-Maria Simundic Croatia
Tommaso Trenti Italy
Cas Weykamp The Netherlands
Maria Willrich USA
Paul Yip Canada

Publisher
Biomedia srl
Via L. Temolo 4, 20126 Milano

Responsible Editor
Giuseppe Agosta

Editorial Secretary
Chiara Riva
Biomedia srl
Via L. Temolo 4, 20126 Milano
Tel. 0245498282
email: biochimica.clinica@sibioc.it

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ISSN print: 0393 – 0564
ISSN digital: 0392- 7091

BC: Articoli scritti da M. Ammirabile

Preziose informazioni dall’esame del liquido pericardico
Valuable information from the examination of the pericardial fluid
A. Sharif Rouhani \| F. Spanu \| C. Ferraris Fusarini \| M. Ammirabile \| A.C. Migliorini \| M. Vidali \| G. Croci \| F. Ceriotti \|
<p><span style="font-family:calibri,sans-serif; font-size:9.0pt">A 63-year-old man, without previously known cancer disease, arrived at the Emergency room because of severe dyspnea. Electrocardiogram revealed right branch block and low ventricular repolarization voltages. Chest X ray and echocardiogram, instead, showed right pleural effusion and cardiac massive effusion. The patient underwent pericardiocentesis. The morphological study of pericardial fluid revealed the presence of numerous nonhematopoietic cells and the patient was admitted to the hosptital Thoracentesis was performed during hospitalization. The analysis of pleural fluid showed similar results to those obtained in pericardial fluid. A subsequent paracentesis was performed. Accordingly, this fluid showed similar atypical cells. Adenopathy in the supraclavicular area was found at the TC scan. Lymphnode biopsy confirmed a poorly differentiated proliferation, consistent with squamous cell carcinoma. In conclusion, morphological analysis of the pericardial fluid is a simple examination that, in a short time, may alert about the presence of unexpected atypical cells.</span></p>
Biochimica Clinica ; 46(3) e18-e21 Casi Clinici - Case Report

Impatto dell’emergenza COVID-19 nei laboratori: esperienze e opinioni dei SIBioC Young Scientists
The impact of COVID-19 emergency in clinical laboratories: experiences and opinions of SIBioC Young Scientists
M. Ammirabile \| A. Aita \| A. Bartolini \| F. Spolaore \| M. Scapaticci \| C. Pellegrini \| M. Perrone \| G. Sancesario \|
<p>The recent pandemic status declared worldwide for the spreading of the new coronavirus-SARS-CoV-2 has emphasized the key role of the Laboratory Medicine in the health care process. In this context, the clinical laboratories needed to rapidly reorganize the internal workflow to face the emergency and to continue ensuring rapid and accurate responses. This has been possible only thanks to the contribution of all the personal working in the laboratory, including administrative staff, nurses, technical staff, and clinical chemists. The competence and the commitment of the Young Scientists (YS), can be considered an essential contribution to the efficient and successful management of the pandemic in clinical laboratories.<br />This paper reports the experiences and the opinions of some of the members of the SIBioC YS Study Group, who have been involved in the clinical laboratory management of the COVID-19 pandemic. The paper is focused to present and discuss the use of the molecular and serological tests for the screening and diagnosis of COVID-19, the reorganization of laboratories, the development of panels of biochemical markers for organ damage and cardiovascular involvement diagnosis. Finally, issues are addressed regarding the importance of safety procedures for biohazard containment, and of future research and development perspectives, thanks to the availability of biological specimens from patients affected by COVID-19, safely and correctly stored in biobanks, together with the associated clinical data.</p>
Biochimica Clinica ; 44(4) 021-022 COVID-19 - COVID-19

La Medicina di Laboratorio: gli specialisti di domani
Laboratory Medicine: specialists of tomorrow
G. Sancesario \| M. A. Perrone \| C. Pellegrini \| C. Ialongo \| A. Aita \| P. Kumar Dabla \| S. Fares Taie \| J. Favresse \| A. Velts-Lindh \| V. D'Argenio \| M. Ammirabile \| F. Spolaore \| C. Renzi \| M. Nuvolone \| F. Cariati \| C. Bellini \| M. Benati \| G.L. Salvagno \| M. Plebani \| S. Bernardini \|
<p>Laboratory Medicine rides the wave of technological progress, the metamorphosis of information systems and data management. The Young Specialist is not a mere observer, but rather takes a leading role in this change, taking advantage of the opportunities offered by “omics” technologies, capturing new ideas and innovative stimuli that lead to a new concept of work and research oriented to health and prevention. Thanks to the support of international web platforms, training and exchange programs supported by the International Scientific Societies and Federations that favor professional and scientific growth, Young Scientists work in a global context. In this scenario, the SIBioC Young Scientists Study Group, with the auspices of SIBioC, EFLM and IFCC, organized a meeting on "Laboratory Medicine: Specialists of tomorrow" with the aim of discussing and highlighting some of the most important challenges, such as technological progress, training and internationalization of young people. Finally, the future of laboratory medicine looks at a multidisciplinary approach that leads to integrated diagnosis, identification of the frail patient, the use of the Point of Care Testing as an indispensable tool in crisis areas, making the dialogue between physician and laboratory specialist a fundamental step for the diagnosis and treatment with the final aim of a better outcome for the patient.</p>
Biochimica Clinica ; 43(4) 424-434 Documenti - Documents

Utilità dell’esame citologico del liquido cerebrospinale
Clinical utility of cerebrospinal fluid cytological examination
C. Ferraris Fusarini \| L. Maldari \| A. Maregnani \| M. Ammirabile \| C. Sina \| R. Maiavacca \| F. Ceriotti \|
<p>Cerebrospinal fluid (CSF) of a 64 year old malepatient was sent from the hematology unit to laboratory for cell count and morphology and chemical-physicalexamination. CSF was clear, colourless and with increased total protein concentration. Cell count was first performedin Burker camera with a result of 40/μL; some of the cells showed an abnormal morphology. Our laboratory workflowincludes the CSF examination utilizing an automatic cell counter: it showed a few white blood cells (3/μL), but a highnumber of total cells (64/μL). The morphological evaluation, with cytocentrifugation and May-Grunwald Giemsa stain,identified the elements as mature plasma cells; the result was then confirmed by immunophenotyping.<br />These findings suggest a neurological localization of a multiple myeloma (MM). Actually, the patient had beendiagnosed as IgA lambda MM, with bone involvement that caused progressive loss of walk. Positron EmissionTomography revealed hyperdense areas, but it wasn’t able to distinguish between lymphoproliferative disease andthrombotic phlogosis. In spite of the therapy, patient neurological conditions worsened till irreversible coma. He dieda few days later.</p>
Biochimica Clinica ; 43(2) e17-e19 Casi Clinici - Case Report